Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El-Mehraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco.
Saâda Laboratory of Medical Analysis, Fez 30000, Morocco.
Medicina (Kaunas). 2023 Oct 12;59(10):1814. doi: 10.3390/medicina59101814.
Paracetamol overdose is a significant global issue due to its widespread use, which can lead to a lack of awareness regarding its potential side effects. Paracetamol can harm the liver, possibly resulting in liver failure. Conversely, this study employed extracts from (PC), known for its rich content of bioactive compounds, with demonstrated antioxidant properties shown in previous research as well as protective effects against various diseases. The primary objective of this study was to investigate the potential protective effects of on altered hematological and biochemical parameters in the blood of rats exposed to paracetamol. The study involved twenty Wistar rats divided into four groups. Different groups of male rats were administered PC extract at 200 mg/kg body weight daily for 15 days, along with a standard reference dose of paracetamol at 200 mg/kg. The study assessed hepatoprotection capacity by analyzing liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profiles. Renal safety was evaluated through creatinine, urea, uric acid, lactate dehydrogenase (LDH), and total protein. Additionally, histopathological examinations of the liver and kidneys were conducted. Following Paracetamol overdose, there were reductions in hemoglobin levels, serum total protein, albumin, and uric acid. Paracetamol overdose also elevated levels of several blood biomarkers, including creatinine, urea, nitrogen, ALT, AST, triglycerides, LDH activity, white blood cell count, and platelet count compared to the control group. However, using an ethanolic extract of significantly mitigated the severity of these alterations and the extent of the effect correlated with the dose administered. Parsley extract helped prevent proteinuria and low hemoglobin, which are common side effects of Paracetamol. Therefore, parsley may hold promise in managing liver and kidney conditions-particularly in addressing proteinuria. Ultimately, these results may have implications for human health by potentially mitigating paracetamol-induced renal, hepatic, and hematological toxicity.
对乙酰氨基酚过量是一个全球性的重大问题，因为它的应用广泛，这可能导致人们对其潜在副作用缺乏认识。对乙酰氨基酚会损害肝脏，可能导致肝衰竭。相反，这项研究采用了 （PC） 的提取物，它含有丰富的生物活性化合物，具有抗氧化特性，在之前的研究中也表现出对各种疾病的保护作用。本研究的主要目的是研究 对乙酰氨基酚暴露大鼠血液中改变的血液学和生化参数的潜在保护作用。研究共涉及 20 只 Wistar 大鼠，分为四组。不同组的雄性大鼠每天给予 200mg/kg 体重的 PC 提取物，同时给予 200mg/kg 的标准参考剂量对乙酰氨基酚。该研究通过分析天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、胆红素、白蛋白等肝酶来评估肝保护能力，以及通过肌酐、尿素、尿酸、乳酸脱氢酶（LDH）和总蛋白来评估肾安全性。此外，还对肝脏和肾脏进行了组织病理学检查。 对乙酰氨基酚过量后，血红蛋白水平、血清总蛋白、白蛋白和尿酸降低。与对照组相比，对乙酰氨基酚过量还会升高几种血液生物标志物的水平，包括肌酐、尿素、氮、ALT、AST、甘油三酯、LDH 活性、白细胞计数和血小板计数。然而，使用 的乙醇提取物显著减轻了这些变化的严重程度，并且作用的程度与给予的剂量相关。欧芹提取物有助于预防蛋白尿和低血红蛋白，这是对乙酰氨基酚的常见副作用。 因此，欧芹可能在治疗肝肾功能障碍方面具有潜力，特别是在解决蛋白尿方面。最终，这些结果可能会对人类健康产生影响，可能会减轻对乙酰氨基酚引起的肾、肝和血液毒性。
