• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

RHBDF2 与肝癌中的免疫浸润相关，可能具有作为生物标志物的潜力。

RHBDF2 is correlated with immune infiltrates in hepatocellular carcinoma and may have potential as a biomarker.

机构信息

Department of Pathology, Molecular Medicine and Cancer Research Center, Basic Medicine College, Chongqing Medical University, Yuzhong, China.

出版信息

FEBS Open Bio. 2023 May;13(5):881-897. doi: 10.1002/2211-5463.13598. Epub 2023 Apr 5.

DOI:10.1002/2211-5463.13598
PMID:36943228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10153346/
Abstract

Immune checkpoint inhibitors have been approved for the treatment of advanced hepatocellular carcinoma (HCC). However, immunotherapy requires the identification of suitable biomarkers to guide treatment. The gene for rhomboid 5 homolog 2 (IRHom2), which encodes the rhombus protease iRhom2, activates the MAP3K7-dependent pathway and promotes hepatic steatosis. Thus, we hypothesized an involvement of this gene in HCC. We report that RHBDF2 expression is dramatically upregulated in HCC. RHBDF2 upregulation is associated with tumor stage, lymph node metastasis, tumor protein P53 mutation, and worse prognoses in HCC patients. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and gene set enrichment analysis enrichment analysis indicated that RHBDF2 was involved in immune signal pathways. Moreover, RHBDF2 expression was positively related not only to immune infiltration, but also to immune cell markers. Examination of several types of HCC infiltrated by immune cells revealed that the group with high expression of RHBDF2 showed the worst outcomes. Therefore, RHBDF2 may have potential as a novel biomarker for predicting prognosis and is related to immune infiltrates in HCC.

摘要

免疫检查点抑制剂已被批准用于治疗晚期肝细胞癌 (HCC)。然而，免疫疗法需要确定合适的生物标志物来指导治疗。 该基因的 rhomboid 5 同源物 2 (IRHom2)，其编码菱形蛋白酶 iRhom2，激活 MAP3K7 依赖性途径，并促进肝脂肪变性。因此，我们假设该基因参与 HCC。我们报告 RHBDF2 在 HCC 中表达显著上调。RHBDF2 的上调与肿瘤分期、淋巴结转移、肿瘤蛋白 P53 突变和 HCC 患者的预后不良有关。基因本体论、京都基因与基因组百科全书和基因集富集分析富集分析表明，RHBDF2 参与免疫信号通路。此外，RHBDF2 的表达不仅与免疫浸润有关，而且与免疫细胞标志物有关。对几种免疫细胞浸润的 HCC 进行检查后发现，RHBDF2 高表达的组显示出最差的结果。因此，RHBDF2 可能具有作为预测预后的新型生物标志物的潜力，并且与 HCC 中的免疫浸润有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/2c9c9b6792ce/FEB4-13-881-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/4d06639654a1/FEB4-13-881-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/b0cebfb57270/FEB4-13-881-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/8947af3f9219/FEB4-13-881-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/f099f7bb3685/FEB4-13-881-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/d3515106f548/FEB4-13-881-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/4633d795d06f/FEB4-13-881-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/08e0968078a1/FEB4-13-881-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/2c9c9b6792ce/FEB4-13-881-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/4d06639654a1/FEB4-13-881-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/b0cebfb57270/FEB4-13-881-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/8947af3f9219/FEB4-13-881-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/f099f7bb3685/FEB4-13-881-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/d3515106f548/FEB4-13-881-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/4633d795d06f/FEB4-13-881-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/08e0968078a1/FEB4-13-881-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e80/10153346/2c9c9b6792ce/FEB4-13-881-g009.jpg

相似文献

1
RHBDF2 is correlated with immune infiltrates in hepatocellular carcinoma and may have potential as a biomarker.RHBDF2 与肝癌中的免疫浸润相关，可能具有作为生物标志物的潜力。
FEBS Open Bio. 2023 May;13(5):881-897. doi: 10.1002/2211-5463.13598. Epub 2023 Apr 5.
2
The prognostic value of RHBDF2 in Pan-Cancer, and its correlation with cell Adhesion of Hepatocellular Carcinoma.RHBDF2 在泛癌症中的预后价值及其与肝癌细胞黏附的相关性。
Biotechnol Genet Eng Rev. 2024 Oct;40(2):1024-1048. doi: 10.1080/02648725.2023.2191092. Epub 2023 Mar 21.
3
High expression of PDZ-binding kinase is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma.PDZ 结合激酶高表达与肝癌预后不良和免疫浸润相关。
World J Surg Oncol. 2022 Jan 22;20(1):22. doi: 10.1186/s12957-021-02479-w.
4
Identification of CFHR4 as a Potential Prognosis Biomarker Associated With lmmune Infiltrates in Hepatocellular Carcinoma.鉴定 CFHR4 作为与肝癌免疫浸润相关的潜在预后生物标志物。
Front Immunol. 2022 Jun 22;13:892750. doi: 10.3389/fimmu.2022.892750. eCollection 2022.
5
Characterization of prognostic value and immunological roles of RAB22A in hepatocellular carcinoma.RAB22A 在肝细胞癌中的预后价值和免疫作用特征。
Front Immunol. 2023 Mar 3;14:1086342. doi: 10.3389/fimmu.2023.1086342. eCollection 2023.
6
Transcriptional analysis of the expression, prognostic value and immune infiltration activities of the COMMD protein family in hepatocellular carcinoma.肝细胞癌中 COMMD 蛋白家族的表达、预后价值和免疫浸润活性的转录分析。
BMC Cancer. 2021 Sep 7;21(1):1001. doi: 10.1186/s12885-021-08699-3.
7
RHBDF2 gene functions are correlated to facilitated renal clear cell carcinoma progression.RHBDF2基因功能与促进肾透明细胞癌进展相关。
Cancer Cell Int. 2021 Nov 4;21(1):590. doi: 10.1186/s12935-021-02277-0.
8
Identification of LOXL3-associating immune infiltration landscape and prognostic value in hepatocellular carcinoma.鉴定 LOXL3 相关免疫浸润图谱及其在肝细胞癌中的预后价值。
Virchows Arch. 2021 Dec;479(6):1153-1165. doi: 10.1007/s00428-021-03193-4. Epub 2021 Aug 27.
9
Comprehensive Analysis of HHLA2 as a Prognostic Biomarker and Its Association With Immune Infiltrates in Hepatocellular Carcinoma.HHLA2作为肝细胞癌预后生物标志物及其与免疫浸润关系的综合分析
Front Immunol. 2022 Mar 17;13:831101. doi: 10.3389/fimmu.2022.831101. eCollection 2022.
10
Coiled-Coil Domain-Containing Protein 45 Is a Potential Prognostic Biomarker and Is Associated with Immune Cell Enrichment of Hepatocellular Carcinoma.卷曲螺旋结构域蛋白 45 是一种潜在的预后生物标志物，并与肝癌的免疫细胞浸润相关。
Dis Markers. 2022 Dec 29;2022:7745315. doi: 10.1155/2022/7745315. eCollection 2022.

本文引用的文献

1
RHBDF2 gene functions are correlated to facilitated renal clear cell carcinoma progression.RHBDF2基因功能与促进肾透明细胞癌进展相关。
Cancer Cell Int. 2021 Nov 4;21(1):590. doi: 10.1186/s12935-021-02277-0.
2
Immunotherapeutic treatments in hepatocellular carcinoma; achievements, challenges and future prospects.肝细胞癌的免疫治疗；成就、挑战与未来展望。
Int Immunopharmacol. 2021 Dec;101(Pt A):108322. doi: 10.1016/j.intimp.2021.108322. Epub 2021 Nov 1.
3
Combining systemic and local therapies for hepatocellular carcinoma.
肝细胞癌的全身治疗与局部治疗联合应用
Lancet Gastroenterol Hepatol. 2021 Dec;6(12):976-978. doi: 10.1016/S2468-1253(21)00388-5. Epub 2021 Oct 23.
4
The progress of immune checkpoint therapy in primary liver cancer.免疫检查点治疗原发性肝癌的进展。
Biochim Biophys Acta Rev Cancer. 2021 Dec;1876(2):188638. doi: 10.1016/j.bbcan.2021.188638. Epub 2021 Oct 22.
5
Metabolic Syndrome and Risk of Gastrointestinal Cancers: An Investigation Using Large-scale Molecular Data.代谢综合征与胃肠道癌症风险：基于大规模分子数据的研究。
Clin Gastroenterol Hepatol. 2022 Jun;20(6):e1338-e1352. doi: 10.1016/j.cgh.2021.10.016. Epub 2021 Oct 20.
6
Functional Assessment of Four Novel Immune-Related Biomarkers in the Pathogenesis of Clear Cell Renal Cell Carcinoma.四种新型免疫相关生物标志物在透明细胞肾细胞癌发病机制中的功能评估
Front Cell Dev Biol. 2021 Mar 16;9:621618. doi: 10.3389/fcell.2021.621618. eCollection 2021.
7
Screening of Potential Biomarkers for Gastric Cancer with Diagnostic Value Using Label-free Global Proteome Analysis.基于无标记全蛋白质组分析的胃癌诊断价值的潜在生物标志物筛选。
Genomics Proteomics Bioinformatics. 2020 Dec;18(6):679-695. doi: 10.1016/j.gpb.2020.06.012. Epub 2021 Feb 17.
8
Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification.肝细胞癌（HCC）：流行病学、病因学和分子分类。
Adv Cancer Res. 2021;149:1-61. doi: 10.1016/bs.acr.2020.10.001. Epub 2020 Nov 28.
9
The Role of iRhom2 in Metabolic and Cardiovascular-Related Disorders.iRhom2在代谢及心血管相关疾病中的作用
Front Cardiovasc Med. 2020 Nov 24;7:612808. doi: 10.3389/fcvm.2020.612808. eCollection 2020.
10
Immuno-oncology for Hepatocellular Carcinoma: The Present and the Future.免疫肿瘤学治疗肝细胞癌：现状与未来。
Clin Liver Dis. 2020 Nov;24(4):739-753. doi: 10.1016/j.cld.2020.07.007. Epub 2020 Sep 2.