Muraki K, Nishi Y, Okahata H, Arai M, Yamada H, Fujita S, Miyachi Y, Ueda K
Department of Pediatrics, Hiroshima University School of Medicine, Japan.
J Pediatr Gastroenterol Nutr. 1987 Mar-Apr;6(2):290-5. doi: 10.1097/00005176-198703000-00023.
The ontogenic development of neurotensin-like immunoreactivity (NTLI) in the gastrointestinal tract was studied in three groups of male rats on different diets. Group I rats were weaned physiologically. Group II rats received only mother's milk until 25 days of age. Group III rats were fed mother's milk alone for 20 days and then switched abruptly to laboratory chow. The NTLI concentration in the gastrointestinal tract from the esophagus to the small intestine was almost the same as that in adult rats before weaning. It increased after weaning to a peak on day 20 or 25, and then decreased to the adult level. The NTLI concentration in the cecum and large intestine, however, decreased from high neonatal level, reaching the adult level on day 20 or 25, and it remained constant thereafter. Prolonged mother's milk feeding alone enhanced neurotensin production in the esophagus and postponed the physiological decrement of NTLI concentrations in the duodenum and small intestine. The sudden change from mother's milk to laboratory chow accelerated the decrement of intestinal NTLI concentrations.
在三组食用不同饮食的雄性大鼠中研究了胃肠道中神经降压素样免疫反应性（NTLI）的个体发生发展。第一组大鼠正常断奶。第二组大鼠在25日龄前仅食用母乳。第三组大鼠单独食用母乳20天，然后突然换成实验室饲料。在断奶前，从食管到小肠的胃肠道中NTLI浓度与成年大鼠几乎相同。断奶后，NTLI浓度升高，在第20天或第25天达到峰值，然后降至成年水平。然而，盲肠和大肠中的NTLI浓度从新生儿期的高水平下降，在第20天或第25天达到成年水平，此后保持恒定。单独延长母乳喂养可增强食管中神经降压素的产生，并推迟十二指肠和小肠中NTLI浓度的生理性下降。从母乳突然换成实验室饲料加速了肠道NTLI浓度的下降。
