Zhang Ruyi, Ni Zemin, Wei Muhong, Cui Yuan, Zhou Haolong, Di Dongsheng, Wang Qi
From the MOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Women and Children Medical Center for Jiang-an District, Wuhan, China.
Menopause. 2023 May 1;30(5):529-538. doi: 10.1097/GME.0000000000002173. Epub 2023 Mar 20.
Osteoporosis is a skeletal disease characterized by low bone mass, reduced bone strength, and increased fracture risk. We aimed to investigate the association between combined dietary antioxidant intake and the likelihood of osteoporosis in premenopausal and postmenopausal women, based on data from the National Health and Nutrition Examination Survey.
Nutrient intake data were obtained using two 24-hour recalls. Composite dietary antioxidant index (CDAI), which refers to the intake amounts of β-carotene, vitamin A, vitamin C, vitamin E, selenium, zinc, copper, and iron, was then constructed. Prevalent osteoporosis was defined according to bone mineral density T scores of ≤ -2.5 and self-reports. Multiple logistic and Poisson regression models were used for association analyses.
A total of 3,418 participants (1,157 premenopausal and 2,261 postmenopausal women) 40 years or older were included, 776 (22.70%) of whom had prevalent osteoporosis. In terms of individual nutrients, postmenopausal women in the highest CDAI quartiles for dietary β-carotene, vitamin A, vitamin C, and iron intakes had a low likelihood of osteoporosis. Regarding the CDAI-osteoporosis association, postmenopausal women in the highest quartile were less likely to have osteoporosis (OR Q3 vs Q1 , 0.64; 95% CI, 0.43-0.96; OR Q4 vs Q1 , 0.56; 95% CI, 0.35-0.89; P for trend = 0.013), after controlling for covariates.
CDAI was negatively associated with the likelihood of osteoporosis in postmenopausal women. Our findings suggest that the combined intake of antioxidant nutrients can help reduce the likelihood of osteoporosis in women.
骨质疏松症是一种以骨量低、骨强度降低和骨折风险增加为特征的骨骼疾病。我们旨在基于美国国家健康与营养检查调查的数据，研究绝经前和绝经后女性联合膳食抗氧化剂摄入量与患骨质疏松症可能性之间的关联。
通过两次24小时膳食回顾获取营养摄入数据。然后构建综合膳食抗氧化剂指数（CDAI），该指数指的是β-胡萝卜素、维生素A、维生素C、维生素E、硒、锌、铜和铁的摄入量。根据骨矿物质密度T值≤ -2.5以及自我报告来定义现患骨质疏松症。使用多元逻辑回归和泊松回归模型进行关联分析。
共纳入3418名40岁及以上的参与者（1157名绝经前女性和2261名绝经后女性），其中776人（22.70%）患有现患骨质疏松症。就个体营养素而言，膳食β-胡萝卜素、维生素A、维生素C和铁摄入量处于CDAI最高四分位数的绝经后女性患骨质疏松症的可能性较低。关于CDAI与骨质疏松症的关联，在控制协变量后，处于最高四分位数的绝经后女性患骨质疏松症的可能性较小（第三四分位数与第一四分位数相比，OR = 0.64；95% CI，0.43 - 0.96；第四四分位数与第一四分位数相比，OR = 0.56；95% CI，0.35 - 0.89；趋势P值 = 0.013）。
CDAI与绝经后女性患骨质疏松症的可能性呈负相关。我们的研究结果表明，抗氧化营养素的联合摄入有助于降低女性患骨质疏松症的可能性。
