Second-year resident in obstetrics and gynecology at McMaster University in Hamilton, Ont.
Second-year resident in physical medicine and rehabilitation at the University of Toronto in Ontario.
Can Fam Physician. 2023 Mar;69(3):192-197. doi: 10.46747/cfp.6903192.
To systematically examine the content of opioid-related advertisements.
Content analysis and quantitative assessment.
North America.
Researchers examined advertisements in 2 issues per year from 1996 to 2016 of , the , and the .
Number of advertisements, nature of the claims made, and quality of cited evidence in the advertisements.
Opioid advertisements composed 89 of the 3173 pharmaceutical advertisements in 210 journal issues searched. Seventy-three advertisements were able to be obtained for analysis. Thirty-four (46.6%) did not mention the addictive potential of opioids, and 54 of 73 (74.0%) did not mention the possibility of death. All referenced studies in advertisements were funded by pharmaceutical organizations or had pharmaceutical company employees as authors. No advertisements cited high-quality evidence.
Many claims of the effectiveness and safety of opioids were published in medical journals through advertisements. Advertisements did not usually mention key negative information about opioids. Although the extent to which these advertisements directly influenced the development of the opioid crisis in North America is unknown, the marked omission of important detrimental effects of opioids may have played a role. Further efforts to restrict opioid marketing may be warranted.
系统地考察阿片类药物相关广告的内容。
内容分析和定量评估。
北美。
研究人员对 1996 年至 2016 年期间《新英格兰医学杂志》、《柳叶刀》和《加拿大医学会杂志》每两年一期的广告进行了检查。
广告数量、广告中声称的性质以及广告中引用证据的质量。
在搜索的 210 期杂志中，3173 个医药广告中有 89 个是阿片类药物广告。有 73 个广告可用于分析。34 个（46.6%）广告未提及阿片类药物的成瘾潜力，54 个（74.0%）广告未提及死亡的可能性。广告中引用的所有研究均由制药组织资助，或有制药公司员工作为作者。没有广告引用高质量的证据。
许多关于阿片类药物有效性和安全性的声明都是通过广告在医学期刊上发表的。广告通常没有提及阿片类药物的关键负面信息。尽管这些广告在多大程度上直接导致了北美阿片类药物危机尚不清楚，但明显遗漏了阿片类药物的重要有害影响可能起到了一定作用。进一步限制阿片类药物营销的努力可能是合理的。
