Department of Surgical Nursing, Faculty of Health Science, Sakarya University, Sakarya, Turkey.
Turk J Med Sci. 2023 Feb;53(1):58-67. doi: 10.55730/1300-0144.5558. Epub 2023 Feb 22.
People have used many natural materials such as plant leaves, roots, liquids derived from plants, and animal products to treat wounds throughout history. It can be said that the research on wound care in recent years have focused on traditional and natural products again. This study aimed to investigate the effects of sweetgum oil, propolis, silk protein, and Ankaferd Blood Stopper (ABS) on wound healing in an experimental excisional wound model.
: Including 36 Balb/c inbreed mice in the study were divided equally into four groups. Two circular excisional wounds were created on the dorsal skin of mice under anesthesia using a punch biopsy device. The wounds of the first group of mice were topically dressed with sweetgum oil, the second group mice with propolis, the third group mice with silk protein, and the fourth group mice with ABS daily. Tissue samples were taken from the wounds of mice on the 7th and 14th day of wound formation, and histological examinations were performed. On the 14th day, the wounds created in all mice were healed, and the experiment was terminated.
Mice in the silk protein group had faster wound healing. There was no statistical difference between the groups in immunohistochemical examinations. In the ABS group, the findings of the inflammatory process were more prominent.
In conclusions, propolis, sweetgum oil, silk protein, and ABS positively affect different parameters in wound healing and support wound healing.
人们在历史上曾使用许多天然材料，如植物叶片、根、植物提取液和动物产品来治疗伤口。可以说，近年来对伤口护理的研究再次关注于传统和天然产品。本研究旨在通过实验性切除伤口模型，研究甜槠油、蜂胶、丝蛋白和 Ankaferd 止血粉（ABS）对伤口愈合的影响。
包括 36 只 Balb/c 近交系小鼠，平均分为四组。使用打孔活检装置在麻醉下对小鼠背部皮肤造成两个圆形切除伤口。第一组小鼠的伤口用甜槠油局部涂抹，第二组小鼠用蜂胶，第三组小鼠用丝蛋白，第四组小鼠每天用 ABS。在伤口形成的第 7 天和第 14 天从小鼠的伤口处采集组织样本，并进行组织学检查。第 14 天，所有小鼠的伤口均愈合，实验结束。
丝蛋白组的小鼠伤口愈合更快。免疫组织化学检查各组之间无统计学差异。在 ABS 组，炎症过程的发现更为明显。
总之，蜂胶、甜槠油、丝蛋白和 ABS 对伤口愈合的不同参数均有积极影响，支持伤口愈合。
