2021 年罗马尼亚一次大规模胃肠炎暴发中检测到的诺如病毒 GII.P17-GII.17 的基因组特征。
Genome characterisation of norovirus GII.P17-GII.17 detected during a large gastroenteritis outbreak in Romania in 2021.
机构信息
Molecular Epidemiology for Communicable Diseases Laboratory, Cantacuzino National Military Medical Institute for Research and Development, 103 Splaiul Independenței, Bucharest, 050096, Romania.
National Institute of Public Health, National Center for Surveillance and Control of Communicable Diseases, 1-3 Doctor Leonte Anastasievici, Bucharest, 050463, Romania.
出版信息
Arch Virol. 2023 Mar 22;168(4):116. doi: 10.1007/s00705-023-05741-6.
Norovirus (NoV) is one of the leading causes of acute gastroenteritis worldwide. Genotype GII.P17-G.II.17 emerged in Asia between 2013 and 2015 and transiently replaced the GII.4 Sydney 2012 variant circulating at that time. We present the genome characterisation of a GII.P17-GII.17 strain causing a large outbreak in Romania in 2021. Our study shows that the 2021 strain belongs to a novel cluster of genotype GII.17, different from the two previously recognised P.17 clusters. Distinctive substitutions in predicted conformational epitopes of VP1 were identified for this new cluster. Also, our phylogenetic analysis showed the existence of another P.17 cluster grouping strains from France and Canada.
诺如病毒（NoV）是全球急性胃肠炎的主要原因之一。基因型 GII.P17-G.II.17 于 2013 年至 2015 年在亚洲出现，并短暂取代了当时流行的 GII.4 Sydney 2012 变体。我们介绍了导致 2021 年罗马尼亚大规模暴发的 GII.P17-GII.17 株的基因组特征。我们的研究表明，2021 年的毒株属于一种新型 GII.17 基因型簇，与之前确认的两个 P.17 簇不同。在预测的 VP1 构象表位中发现了这个新簇的独特取代。此外，我们的系统发育分析显示，来自法国和加拿大的菌株存在另一个 P.17 簇。
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