Foxp3 基因在调节性 T 细胞功能中的分析。
Genomic Analysis of Foxp3 Function in Regulatory T Cells.
机构信息
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ.
Quantitative and Computational Biology Graduate Program, Princeton University, Princeton, NJ.
出版信息
J Immunol. 2023 Apr 1;210(7):880-887. doi: 10.4049/jimmunol.2200864.
Abstract
Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor controlling Treg cell differentiation and function. In this article, we review the current mechanistic and systemic understanding of Foxp3 function enabled by experimental and computational advances in high-throughput genomics.
摘要
调节性 T（Treg）细胞对于耐受自身抗原和预防自身免疫至关重要。Foxp3 已被确定为一种 Treg 细胞谱系定义转录因子，控制 Treg 细胞分化和功能。在本文中，我们通过高通量基因组学的实验和计算进展，综述了对 Foxp3 功能的当前机制和系统理解。
相似文献
1
Genomic Analysis of Foxp3 Function in Regulatory T Cells.Foxp3 基因在调节性 T 细胞功能中的分析。
J Immunol. 2023 Apr 1;210(7):880-887. doi: 10.4049/jimmunol.2200864.
2
Control of regulatory T-cell differentiation and function by T-cell receptor signalling and Foxp3 transcription factor complexes.调控性 T 细胞分化和功能的 T 细胞受体信号和 Foxp3 转录因子复合物。
Immunology. 2020 May;160(1):24-37. doi: 10.1111/imm.13178. Epub 2020 Mar 9.
3
Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions.组蛋白甲基化通过调节特征基因表达来介导人 FOXP3(+)调节性 T 细胞的可塑性。
Immunology. 2014 Mar;141(3):362-76. doi: 10.1111/imm.12198.
4
Regulatory T Cells: the Many Faces of Foxp3.调节性 T 细胞：Foxp3 的多面性。
J Clin Immunol. 2019 Oct;39(7):623-640. doi: 10.1007/s10875-019-00684-7. Epub 2019 Sep 2.
5
Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans.小鼠和人类中Foxp3⁺调节性T细胞的功能动力学
Immunol Rev. 2014 May;259(1):140-58. doi: 10.1111/imr.12168.
6
Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation.调控健康与自身免疫中 Foxp3 表达的分子机制：从表观遗传至翻译后调控。
Front Immunol. 2020 Feb 3;10:3136. doi: 10.3389/fimmu.2019.03136. eCollection 2019.
7
Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3.人类调节性 T 细胞（Treg）分化的时分辨转录组和蛋白质组图谱揭示了 FOXP3 的新调节因子。
BMC Biol. 2018 May 7;16(1):47. doi: 10.1186/s12915-018-0518-3.
8
The role of transcription factors in shaping regulatory T cell identity.转录因子在调节性 T 细胞身份塑造中的作用。
Nat Rev Immunol. 2023 Dec;23(12):842-856. doi: 10.1038/s41577-023-00893-7. Epub 2023 Jun 19.
9
Regulatory T Cells for Control of Autoimmunity.调节性 T 细胞在自身免疫控制中的作用
Adv Exp Med Biol. 2024;1444:67-82. doi: 10.1007/978-981-99-9781-7_5.
10
From stability to dynamics: understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamics.从稳定性到动态性：通过 Foxp3 转录动态理解调节性 T 细胞的分子机制。
Clin Exp Immunol. 2019 Jul;197(1):14-23. doi: 10.1111/cei.13194. Epub 2018 Sep 17.
引用本文的文献
1
Regulatory T cells and their role in allergic disease.调节性T细胞及其在过敏性疾病中的作用。
Allergy. 2025 Jan;80(1):77-93. doi: 10.1111/all.16326. Epub 2024 Sep 27.
2
Adipose-Derived Mesenchymal Stem Cells from Arthritis Patients: Differential Modulation of CD4⁺ T Cell Activation and Cytokine Production.关节炎患者脂肪来源间充质干细胞：调节 CD4⁺T 细胞活化和细胞因子产生的差异。
Med Sci Monit. 2024 Nov 15;30:e945273. doi: 10.12659/MSM.945273.
3
Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4 regulatory T cells by regulating IL2RA.长非编码 RNA LIRIL2R 通过调节 IL2RA 来调节 FOXP3 水平和人 CD4 调节性 T 细胞的抑制功能。
Proc Natl Acad Sci U S A. 2024 Jun 4;121(23):e2315363121. doi: 10.1073/pnas.2315363121. Epub 2024 May 28.
4
Targeting T regulatory (T) cells in immunotherapy-resistant cancers.在免疫治疗耐药性癌症中靶向调节性T细胞。
Cancer Drug Resist. 2024 Jan 12;7:2. doi: 10.20517/cdr.2023.46. eCollection 2024.
5
Reprogramming of Treg cells in the inflammatory microenvironment during immunotherapy: a literature review.免疫治疗中炎症微环境中 Treg 细胞的重编程：文献综述。
Front Immunol. 2023 Sep 11;14:1268188. doi: 10.3389/fimmu.2023.1268188. eCollection 2023.
本文引用的文献
1
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.转录因子 FoxP3 可以折叠成两种二聚化状态，这对调节性 T 细胞功能和免疫稳态有不同的影响。
Immunity. 2022 Aug 9;55(8):1354-1369.e8. doi: 10.1016/j.immuni.2022.07.002. Epub 2022 Aug 3.
2
FOXP3 exon 2 controls T stability and autoimmunity.FOXP3 外显子 2 控制 T 细胞稳定性和自身免疫。
Sci Immunol. 2022 Jun 24;7(72):eabo5407. doi: 10.1126/sciimmunol.abo5407.
3
TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors.TCF-1 促进 T 细胞祖细胞中拓扑关联域之间的染色质相互作用。
Nat Immunol. 2022 Jul;23(7):1052-1062. doi: 10.1038/s41590-022-01232-z. Epub 2022 Jun 20.
4
BCL6-dependent TCF-1 progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen.BCL6 依赖性 TCF-1 祖细胞维持效应器和辅助性 CD4 T 细胞对持续性抗原的应答。
Immunity. 2022 Jul 12;55(7):1200-1215.e6. doi: 10.1016/j.immuni.2022.05.003. Epub 2022 May 27.
5
Single-cell immunology: Past, present, and future.单细胞免疫组学：过去、现在与未来。
Immunity. 2022 Mar 8;55(3):393-404. doi: 10.1016/j.immuni.2022.02.006.
6
Challenges of CRISPR-Based Gene Editing in Primary T Cells.基于 CRISPR 的基因编辑在原代 T 细胞中的挑战。
Int J Mol Sci. 2022 Feb 1;23(3):1689. doi: 10.3390/ijms23031689.
7
FoxP3 associates with enhancer-promoter loops to regulate T-specific gene expression.FoxP3 与增强子-启动子环结合，以调节 T 细胞特异性基因表达。
Sci Immunol. 2022 Jan 14;7(67):eabj9836. doi: 10.1126/sciimmunol.abj9836.
8
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.调节性 T 细胞在已建立的全身炎症中发挥作用，并逆转致命的自身免疫。
Nat Immunol. 2021 Sep;22(9):1163-1174. doi: 10.1038/s41590-021-01001-4. Epub 2021 Aug 23.
9
Runx Transcription Factors in T Cells-What Is Beyond Thymic Development?Runx 转录因子在 T 细胞中的作用——胸腺发育之外的意义是什么？
Front Immunol. 2021 Aug 6;12:701924. doi: 10.3389/fimmu.2021.701924. eCollection 2021.
10
Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacity.Foxp3 增强子协同作用以最大限度地提高调节性 T 细胞的抑制能力。
J Exp Med. 2021 Aug 2;218(8). doi: 10.1084/jem.20202415. Epub 2021 Jun 4.
Zotero 插件