Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, PR China; National Clinical Research Center for Child Health and Disorders, Chongqing, PR China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, PR China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, PR China; Chongqing Key Laboratory of Pediatrics, Chongqing, PR China.
Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, PR China; National Clinical Research Center for Child Health and Disorders, Chongqing, PR China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, PR China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, PR China; Chongqing Key Laboratory of Pediatrics, Chongqing, PR China.
J Affect Disord. 2023 Jun 15;331:175-183. doi: 10.1016/j.jad.2023.03.054. Epub 2023 Mar 21.
Depression is a major public health problem, and epilepsy and a high-inflammatory diet are important causes of depression. We aimed to explore the level of dietary inflammation in epileptic patients and its relationship with moderate to severe depression (MSD).
This cross-sectional study included 12,788 participants aged 20-80 years from the NHANES database from 2013 to 2018. Depressive symptoms were evaluated using the nine-item Patient Health Questionnaire (PHQ-9), and epilepsy was diagnosed based on the use of antiepileptic drugs within the previous 30 days. Dietary inflammatory index (DII) scores and energy-adjusted DII (E-DII) scores were calculated based on dietary recalls of the past 24 h, and average DII (ADII) and energy-adjusted ADII (E-ADII) were calculated based on two 24-hour dietary recalls.
The DII, E-DII, and ADII scores and prevalence of MSD were significantly increased in epileptic patients compared with non-epilepsy subjects. The E-ADII score (P = 0.078) was weakly associated with comorbid MSD in patients with epilepsy. Mediation models showed that dietary inflammation scores mediated 2.31 % to 12.25 % of epilepsy-related MSD. In stratified analysis, an increased prevalence of MSD was present in the Quartile 2 subgroup based on DII and E-ADII scores and in the Quartile 3 subgroup of epileptic patients based on DII, E-DII, and ADII scores.
Epileptics consume more proinflammatory foods and nutrients than control subjects. MSD in patients with epilepsy is associated with their high inflammatory diet. Suggesting an urgent need for rational dietary management in the epileptic population.
抑郁症是一个主要的公共卫生问题，癫痫和高炎症饮食是导致抑郁症的重要原因。我们旨在探讨癫痫患者的饮食炎症水平及其与中重度抑郁（MSD）的关系。
这项横断面研究纳入了 2013 年至 2018 年 NHANES 数据库中 12788 名年龄在 20-80 岁的参与者。使用九项患者健康问卷（PHQ-9）评估抑郁症状，根据过去 30 天内使用抗癫痫药物诊断癫痫。根据过去 24 小时的饮食回忆计算饮食炎症指数（DII）评分和能量校正的 DII（E-DII）评分，并根据两次 24 小时饮食回忆计算平均 DII（ADII）和能量校正的 ADII（E-ADII）。
与非癫痫患者相比，癫痫患者的 DII、E-DII 和 ADII 评分以及 MSD 的患病率显著升高。E-ADII 评分（P=0.078）与癫痫患者共患 MSD 呈弱相关。中介模型表明，饮食炎症评分介导了癫痫相关 MSD 的 2.31%-12.25%。分层分析显示，DII 和 E-ADII 评分的 Quartile 2 亚组和 DII、E-DII 和 ADII 评分的 Quartile 3 亚组中，癫痫患者的 MSD 患病率增加。
癫痫患者比对照人群摄入更多促炎食物和营养素。癫痫患者的 MSD 与其高炎症饮食有关。这表明癫痫患者迫切需要进行合理的饮食管理。
