He Xingyan, Li Zhiling, Wu Haotian, Wang Lifen, Zhang Yuxin
Department of Pediatrics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Shantou University Medical College, Shantou, Guangdong, China.
Front Neurol. 2024 Dec 3;15:1434179. doi: 10.3389/fneur.2024.1434179. eCollection 2024.
Psychiatric disorders is a major public health problem and epilepsy contributes significantly to depression. We aimed to explore the relationship between dietary patterns and mental illness in patients with epilepsy.
The data presented here are based on the 2013-2018 National Health and Nutrition Examination Survey (NHANES). In this study, the t-test and chi-square tests or one-way analysis of variance (ANOVA) were employed for the analysis of continuous and categorical variables, respectively. Restricted cubic splines (RCSs) with four knots were employed to investigate the linear relationship and trend between the Composite Dietary Antioxidant Index (CDAI) and epilepsy and psychiatric disorders, respectively. In instances where the linear relationship was not deemed to be applicable, the CDAI was categorized into four groups based on quartiles. A logistic regression analysis was employed to investigate the relationship between epilepsy and mental disorders under four distinct models. A mediation analysis was employed to ascertain whether CDAI acted as a mediator in the relationship between epilepsy and mental disorders.
Patients with epilepsy had a significantly lower CDAI ( < 0.001) and a significantly higher prevalence of psychiatric disorders ( = 0.02) compared with non-epileptic patients. Mediation modeling showed that CDAI mediated between 3.17 and 5.21% of epilepsy-related psychiatric disorders. In stratified analyses, the prevalence of psychiatric disorders was increased in the second quartile subgroup and the third quartile subgroup of the CDAI dietary index in patients with epilepsy compared with non-epileptic patients.
Our findings suggest that patients with epilepsy have a high risk of developing psychiatric disorders and that the Composite Dietary Antioxidant Index (CDAI) plays a key role in mediating the relationship between epilepsy and psychiatric disorders.
精神障碍是一个重大的公共卫生问题，癫痫对抑郁症有显著影响。我们旨在探讨癫痫患者的饮食模式与精神疾病之间的关系。
此处呈现的数据基于2013 - 2018年美国国家健康与营养检查调查（NHANES）。在本研究中，分别采用t检验和卡方检验或单因素方差分析（ANOVA）对连续变量和分类变量进行分析。采用具有四个节点的受限立方样条（RCS）分别研究复合膳食抗氧化指数（CDAI）与癫痫和精神障碍之间的线性关系及趋势。在认为线性关系不适用的情况下，根据四分位数将CDAI分为四组。采用逻辑回归分析在四种不同模型下研究癫痫与精神障碍之间的关系。采用中介分析确定CDAI是否在癫痫与精神障碍的关系中起中介作用。
与非癫痫患者相比，癫痫患者的CDAI显著更低（<0.001），精神障碍患病率显著更高（=0.02）。中介模型显示，CDAI介导了3.17%至5.21%的癫痫相关精神障碍。在分层分析中，与非癫痫患者相比，癫痫患者中CDAI饮食指数第二四分位数亚组和第三四分位数亚组的精神障碍患病率有所增加。
我们的研究结果表明，癫痫患者发生精神障碍的风险较高，复合膳食抗氧化指数（CDAI）在介导癫痫与精神障碍的关系中起关键作用。
