Department of Chemistry, Universitat Basel, Mattenstrasse 24a, Basel, CH-4058, Switzerland.
National Centre for Competence in Research - Molecular Systems Engineering, Mattenstrasse 24a, Basel, CH-4058, Switzerland.
Macromol Biosci. 2023 Aug;23(8):e2200474. doi: 10.1002/mabi.202200474. Epub 2023 Mar 22.
Polymeric nano- and microscale materials bear significant potential in manifold applications related to biomedicine. This is owed not only to the large chemical diversity of the constituent polymers, but also to the various morphologies these materials can achieve, ranging from simple particles to intricate self-assembled structures. Modern synthetic polymer chemistry permits the tuning of many physicochemical parameters affecting the behavior of polymeric nano- and microscale materials in the biological context. In this Perspective, an overview of the synthetic principles underlying the modern preparation of these materials is provided, aiming to demonstrate how advances in and ingenious implementations of polymer chemistry fuel a range of applications, both present and prospective.
聚合物纳米和微尺度材料在与生物医药相关的多种应用中具有重要的潜力。这不仅归因于组成聚合物的巨大化学多样性,还归因于这些材料可以实现的各种形态,从简单的颗粒到复杂的自组装结构。现代合成聚合物化学允许调整许多影响聚合物纳米和微尺度材料在生物环境中行为的物理化学参数。在本观点中,提供了现代制备这些材料的合成原理概述,旨在展示聚合物化学的进步和巧妙应用如何推动一系列当前和未来的应用。