College of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China; Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Fitoterapia. 2024 Sep;177:106086. doi: 10.1016/j.fitote.2024.106086. Epub 2024 Jun 17.
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease (AD). Currently, there is no cure for PD, and medications can only control the progression of the disease. Various experimental studies have shown the significant efficacy of TCM in treating PD, and combination with western medicine can enhance the effects and reduce toxicity. Thus, exploring effective anti-PD compounds from TCM has become a popular research fields. This review summarizes commonly used TCM extracts and natural products for the treatment of PD, both domestically and internationally. Furthermore, it delves into various mechanisms of TCM in treating PD, such as anti-oxidative stress, anti-inflammatory, anti-apoptotic, improve mitochondrial dysfunction, inhibits α-synuclein (α-Syn) misfolding and aggregation, regulating neurotransmitters, regulates intestinal flora, enhances immunity, and so on. The results reveal that most TCMs exert their neuroprotective effects through anti-inflammatory and anti-oxidative stress actions, thereby slowing down the progression of the disease. These TCM may hold the key to improving PD therapy and have tremendous potential to be developed as novel anti-PD drugs.
帕金森病（PD）是仅次于阿尔茨海默病（AD）的第二大常见神经退行性疾病。目前，PD 尚无治愈方法，药物只能控制疾病的进展。各种实验研究表明，中医药在治疗 PD 方面具有显著疗效，与西药联合使用可以增强疗效，降低毒性。因此，从中医药中探索有效的抗 PD 化合物已成为热门的研究领域。本综述总结了国内外常用于治疗 PD 的中医药提取物和天然产物，并深入探讨了中医药治疗 PD 的多种机制，如抗氧化应激、抗炎、抗细胞凋亡、改善线粒体功能、抑制α-突触核蛋白（α-Syn）错误折叠和聚集、调节神经递质、调节肠道菌群、增强免疫力等。结果表明，大多数中医药通过抗炎和抗氧化应激作用发挥其神经保护作用，从而减缓疾病的进展。这些中医药可能是改善 PD 治疗的关键，具有巨大的潜力可开发为新型抗 PD 药物。
