非剥脱性1927纳米掺铥光纤分数激光治疗亚洲皮肤光老化疗效及安全性的前瞻性研究

Prospective study of efficacy and safety of non-ablative 1927 nm fractional thulium fiber laser in Asian skin photoaging.

作者信息

Li Xianwen, Qin Si, Shi Siman, Feng Yingjun, Li Huarun, Feng Yuqin, Li Mujin, Wen Ju

机构信息

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Department of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, China.

出版信息

Front Surg. 2023 Mar 6;10:1076848. doi: 10.3389/fsurg.2023.1076848. eCollection 2023.

DOI:10.3389/fsurg.2023.1076848

PMID:36950052

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10025463/

Abstract

BACKGROUND AND OBJECTIVE

Photoaging manifests as deeper wrinkles and larger pores. It has been tried to rejuvenate photoaging skin using a variety of lasers, including fractionated lasers, which are a popular photorejuvenation treatment. A new breakthrough for skin rejuvenation is the 1927 nm fractional thulium fiber laser (FTL), a laser and light-based treatment option. Clinical data regarding the FTL for treating photoaging are limited despite its effectiveness and safety. This study is aim to evaluate FTL' clinical effectiveness and safety.

METHODS

Fitzpatrick skin types II-IV subjects with mild to moderate photoaging signs were enrolled in this prospective study. At intervals of one month, patients received three full face treatments. Wrinkles, spots, texture, pores, melanin index, erythema index (MI and EI), skin elasticity and hydration were measured with non-invasive tool. The epidermal thickness and dermal density on ultrasonography were compared between baseline and one month after all treatment sessions. The Global Score for Photoaging scale (GSP) was rated by two independent evaluators at the baseline and final follow-up visit. Secondary outcomes included patient-rated pain on a 10-point visual analog scale (VAS), as well as overall satisfaction. Following each treatment, adverse events were noted.

RESULTS

Totally 27 subjects (24 females and 3 males) with Fitzpatrick skin types II to IV and a mean age of 44.41 (range33-64) were enrolled. Results suggests that the epidermal thickness has significantly improved after treatment. Statistically significant improvements in melanin index, skin elasticity and wrinkles were noted. An analysis of 12 subjects' reports (44%) suggested their skin felt brighter. No post-inflammatory hyperpigmentation changes or adverse events were observed. 70% patients reporting "satisfied" or "extremely satisfied".

CONCLUSIONS

In this study, FTL was found to be a safe and effective treatment option for treating photoaging.

摘要

背景与目的

光老化表现为更深的皱纹和更大的毛孔。人们尝试使用多种激光，包括分次激光（一种流行的光嫩肤治疗方法）来使光老化皮肤恢复活力。皮肤年轻化的一项新突破是1927纳米分次铥光纤激光（FTL），这是一种基于激光和光的治疗选择。尽管FTL治疗光老化有效且安全，但其相关临床数据有限。本研究旨在评估FTL的临床有效性和安全性。

方法

招募了具有轻度至中度光老化迹象的Fitzpatrick II-IV型皮肤受试者参与这项前瞻性研究。患者每隔一个月接受三次全脸治疗。使用非侵入性工具测量皱纹、斑点、质地、毛孔、黑色素指数、红斑指数（MI和EI）、皮肤弹性和水合作用。比较所有治疗疗程结束后一个月与基线时超声检查的表皮厚度和真皮密度。由两名独立评估者在基线和最终随访时对光老化全球评分量表（GSP）进行评分。次要结果包括患者使用10分视觉模拟量表（VAS）对疼痛的评分以及总体满意度。每次治疗后记录不良事件。

结果

共招募了27名受试者（24名女性和3名男性），Fitzpatrick皮肤类型为II至IV型，平均年龄为44.41岁（范围33 - 64岁）。结果表明治疗后表皮厚度有显著改善。黑色素指数、皮肤弹性和皱纹有统计学意义的显著改善。对12名受试者（44%）的报告分析表明他们感觉皮肤更亮了。未观察到炎症后色素沉着变化或不良事件。70%的患者报告“满意”或“非常满意”。