Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Dermatol Surg. 2013 Jun;39(6):879-88. doi: 10.1111/dsu.12176. Epub 2013 Mar 6.
Although the 1,927-nm thulium fiber fractional laser is effective and safe for treating photoaging, clinical data regarding this modality remain limited.
To investigate the efficacy and safety of the 1,927-nm thulium fiber fractional laser for treating photoaging and melasma in Asians.
Twenty-five participants received three laser treatments (at 3-week intervals) on the half of the face with more-severe photoaging and melasma. Independent investigators evaluated clinical improvement 2 and 6 months after the final treatment. Improvement in melasma was evaluated using the Melasma Area and Severity Index. Subjective satisfaction rates were also evaluated. Adverse events were assessed, and pain was scored using a visual analog scale (VAS). Histologic changes were observed using immunohistochemical staining.
Clinical improvement of photodamaged facial skin was remarkable on the treatment side. Most participants reported that their subjective satisfaction rate was greater than slight satisfaction. Downtime for healing required approximately 1 week. No severe adverse events occurred. Mean VAS score during treatment was 4.8. Collagen regeneration and melanin decrease were observed histologically.
The 1,927-nm thulium fiber fractional laser is a safe, effective treatment for photoaging and melasma in Asians.
虽然 1927nm 铥光纤分激光在治疗光老化方面有效且安全，但该治疗方式的临床数据仍有限。
探究 1927nm 铥光纤分激光治疗亚洲人光老化和黄褐斑的疗效和安全性。
25 名参与者接受了三次激光治疗（每 3 周一次），治疗半张面部中光老化和黄褐斑较严重的区域。独立研究者在末次治疗后 2 个月和 6 个月评估临床改善情况。使用黄褐斑面积和严重指数评估黄褐斑的改善情况。还评估了主观满意度。评估了不良反应，并使用视觉模拟评分法（VAS）评估疼痛程度。使用免疫组化染色观察组织学变化。
治疗侧光损伤面部皮肤的临床改善显著。大多数参与者报告他们的主观满意度大于轻微满意度。愈合的停机时间约为 1 周。未发生严重不良事件。治疗期间的平均 VAS 评分为 4.8。组织学观察到胶原再生和黑色素减少。
1927nm 铥光纤分激光是治疗亚洲人光老化和黄褐斑的一种安全、有效的方法。
