Wei Shanshan, Leng Bing, Yan Genquan
Department of Graduate, Shandong Academy of Medical Sciences, Shandong First Medical University, Jinan, China.
Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Front Neurosci. 2023 Mar 6;17:1128087. doi: 10.3389/fnins.2023.1128087. eCollection 2023.
The central nervous system (CNS) is the primary regulator of physiological activity, and when CNS is compromised, its physical functions are affected. Spinal cord injury (SCI) and traumatic brain injury (TBI) are common trauma in CNS that are difficult to recover from, with a higher global disability and mortality rate. Autophagy is familiar to almost all researchers due to its role in regulating the degradation and recycling of cellular defective or incorrect proteins and toxic components, maintaining body balance and regulating cell health and function. Emerging evidence suggests it has a broad and long-lasting impact on pathophysiological process such as oxidative stress, inflammation, apoptosis, and angiogenesis, involving the alteration of autophagy marker expression and function recovery. Changes in autophagy level are considered a potential therapeutic strategy and have shown promising results in preclinical studies for neuroprotection following traumatic brain injury. However, the relationship between upward or downward autophagy and functional recovery following SCI or TBI is debatable. This article reviews the regulation and role of autophagy in repairing CNS trauma and the intervention effects of autophagy-targeted therapeutic agents to find more and better treatment options for SCI and TBI patients.
中枢神经系统（CNS）是生理活动的主要调节者，当中枢神经系统受损时，其身体功能会受到影响。脊髓损伤（SCI）和创伤性脑损伤（TBI）是中枢神经系统常见的创伤，难以恢复，全球残疾和死亡率较高。自噬几乎为所有研究人员所熟知，因为它在调节细胞缺陷或错误蛋白质以及有毒成分的降解和循环利用、维持身体平衡以及调节细胞健康和功能方面发挥作用。新出现的证据表明，它对氧化应激、炎症、细胞凋亡和血管生成等病理生理过程具有广泛而持久的影响，涉及自噬标志物表达的改变和功能恢复。自噬水平的变化被认为是一种潜在的治疗策略，并且在创伤性脑损伤后神经保护的临床前研究中已显示出有希望的结果。然而，SCI或TBI后自噬上调或下调与功能恢复之间的关系仍存在争议。本文综述了自噬在修复中枢神经系统创伤中的调节作用和作用，以及自噬靶向治疗药物的干预效果，以便为SCI和TBI患者找到更多更好的治疗选择。
