用混合磁共振光声断层扫描监测小鼠脑灌注
Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography.
作者信息
Ren Wuwei, Deán-Ben Xosé Luís, Skachokova Zhiva, Augath Mark-Aurel, Ni Ruiqing, Chen Zhenyue, Razansky Daniel
机构信息
Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zurich 8052, Switzerland.
Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich 8093, Switzerland.
出版信息
Biomed Opt Express. 2023 Feb 17;14(3):1192-1204. doi: 10.1364/BOE.482205. eCollection 2023 Mar 1.
Progress in brain research critically depends on the development of next-generation multi-modal imaging tools capable of capturing transient functional events and multiplexed contrasts noninvasively and concurrently, thus enabling a holistic view of dynamic events . Here we report on a hybrid magnetic resonance and optoacoustic tomography (MROT) system for murine brain imaging, which incorporates an MR-compatible spherical matrix array transducer and fiber-based light illumination into a 9.4 T small animal scanner. An optimized radiofrequency coil has further been devised for whole-brain interrogation. System's utility is showcased by acquiring complementary angiographic and soft tissue anatomical contrast along with simultaneous dual-modality visualization of contrast agent dynamics .
脑研究的进展严重依赖于下一代多模态成像工具的开发，这些工具能够无创且同时捕获瞬态功能事件和多重对比度，从而实现对动态事件的整体观察。在此，我们报告一种用于小鼠脑成像的混合磁共振与光声断层扫描（MROT）系统，该系统将一个与磁共振兼容的球形矩阵阵列换能器和基于光纤的光照明整合到一台9.4 T小动物扫描仪中。还设计了一种优化的射频线圈用于全脑检测。通过获取互补的血管造影和软组织解剖对比度以及同时对造影剂动力学进行双模态可视化，展示了该系统的实用性。
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