Nutritional Genomics Research Group, Nutrition and Health Graduation Program, School of Nutrition, Federal University of Goiás, Rua 227, S/N, Quadra 68, Leste Universitário, Goiânia, GO, CEP: 74605080, Brazil.
J Bone Miner Metab. 2023 Jul;41(4):512-521. doi: 10.1007/s00774-023-01417-y. Epub 2023 Mar 23.
This study aimed to evaluate, for the first time, the bone profile of adult women and men with and without normal-weight obesity (NWO) syndrome and its association with bone health-related nutrient intake, anthropometry, and body composition.
This was a cross-sectional study of adults aged between 20 and 59 years with normal body weight, separated according to body fat (BF) percentage into NWO and non-NWO syndrome groups. BF > 30% and > 19% were considered high for women and men, respectively. Socioeconomic, physical activity, food consumption, anthropometric, and body composition data were evaluated. Student's t-test or Mann-Whitney test and Pearson's χ or Fisher's exact tests were applied for comparisons. Multiple linear regression models were developed, with bone parameters as the dependent variables and anthropometric, body composition, and food consumption data as the main independent variables.
The sample consisted of 224 adults (69.2% women) with a median (interquartile range) age of 23 (21-25) years, 71% of whom had NWO syndrome. Compared with women, a higher percentage of men had a lower-than-expected spinal bone mineral density (BMD) Z-score for age (10%; p = 0.0214). Bone parameters were similar between groups. Spinal BMD was negatively associated with male sex and positively associated with body weight. The femoral BMD was negatively associated with BF percentage and positively associated with body mass index.
The negative association of BMD with BF percentage may suggest a higher risk of bone alterations in individuals with NWO syndrome and should be monitored over time.
本研究首次评估了正常体重肥胖（NWO）综合征患者和非 NWO 综合征患者的成人男女骨量特征，及其与骨健康相关营养素摄入、人体测量学和身体成分的关系。
这是一项横断面研究，纳入了年龄在 20 至 59 岁之间、体重正常的成年人，并根据体脂肪（BF）百分比分为 NWO 和非 NWO 综合征组。女性 BF 超过 30%和男性 BF 超过 19%分别被认为过高。评估了社会经济状况、体力活动、食物消耗、人体测量学和身体成分数据。应用学生 t 检验或曼-惠特尼检验和皮尔逊 χ 检验或 Fisher 确切检验进行比较。开发了多元线性回归模型，将骨骼参数作为因变量，人体测量学、身体成分和食物消耗数据作为主要自变量。
样本由 224 名成年人（69.2%为女性）组成，中位数（四分位间距）年龄为 23（21-25）岁，其中 71%患有 NWO 综合征。与女性相比，男性中预计更低的脊柱骨密度（BMD）年龄 Z 评分的比例更高（10%；p=0.0214）。两组之间的骨骼参数相似。脊柱 BMD 与男性性别呈负相关，与体重呈正相关。股骨 BMD 与 BF 百分比呈负相关，与体重指数呈正相关。
BMD 与 BF 百分比呈负相关，这可能表明 NWO 综合征患者的骨骼改变风险更高，应随着时间进行监测。
