体重正常的肥胖成年人的全身骨矿物质密度和骨稳态标志物。
Whole-body bone mineral density and markers of bone homeostasis in adults with normal-weight obesity.
作者信息
Keirns Bryant H, Sciarrillo Christina M, Medlin Austin R, Hart Samantha M, Cronic Elyse M, Emerson Sam R
机构信息
Department of Nutritional Sciences, Oklahoma State University 301 Nancy Randolph Davis, Stillwater, OK, 74078, USA.
Department of Health & Wellness Design, Indiana University School of Public Health, 1025 E. Seventh St., Bloomington, IN, 47405, USA.
出版信息
Obes Pillars. 2023 Jun 1;7:100073. doi: 10.1016/j.obpill.2023.100073. eCollection 2023 Sep.
BACKGROUND
Normal-weight obesity (NWO) describes individuals with a normal body mass index (BMI), but high body fat percent. NWO are at-risk for cardiometabolic diseases, but little is known about their bone health.
METHODS
Adults (N = 24) were classified as NWO (n = 12; 5M/7F) or low body fat percent controls (Con; n = 12; 6M/6F). Body composition and whole-body bone mineral density (BMD) were assessed using DXA. A serum bioplex assay was performed to examine markers related to bone formation and resorption.
RESULTS
In addition to higher body fat percent and visceral fat, NWO had lower whole-body BMD relative to Con ('s < 0.05). Circulating leptin was higher in NWO than Con ( < 0.05). Two biomarkers generally associated with lower bone mass - sclerostin and parathyroid hormone - were higher in NWO compared to Con ('s < 0.05).
CONCLUSION
In this preliminary study, adults with NWO displayed lower whole-body BMD alongside evidence of bone resorption. Impaired bone health may be another subclinical risk factor present in NWO.
背景
正常体重肥胖（NWO）指的是身体质量指数（BMI）正常但体脂百分比高的个体。NWO有患心脏代谢疾病的风险，但人们对他们的骨骼健康知之甚少。
方法
将成年人（N = 24）分为NWO组（n = 12；5名男性/7名女性）或低体脂百分比对照组（Con；n = 12；6名男性/6名女性）。使用双能X线吸收法（DXA）评估身体成分和全身骨矿物质密度（BMD）。进行血清生物芯片检测以检查与骨形成和骨吸收相关的标志物。
结果
除了体脂百分比和内脏脂肪较高外，NWO的全身BMD相对于Con较低（P < 0.05）。NWO的循环瘦素水平高于Con（P < 0.05）。与Con相比，NWO中通常与较低骨量相关的两种生物标志物——硬化蛋白和甲状旁腺激素——更高（P < 0.05）。
结论
在这项初步研究中，患有NWO的成年人全身BMD较低，同时有骨吸收的证据。骨骼健康受损可能是NWO中存在的另一种亚临床风险因素。
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