Koga S, Takebayashi M, Kaibara N, Nishidoi H, Kimura O, Kawasumi H, Makino M
1st Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
J Surg Oncol. 1987 Dec;36(4):239-42. doi: 10.1002/jso.2930360405.
The pathologic characteristics of gastric cancer in 57 patients with hematogenous recurrence were pathologically analyzed by the site of recurrence. In recurrence of gastric cancer that developed in the liver, macroscopic observation revealed that cancers of Borrmann type 2 and 3 were most frequent. Microscopic examination revealed that the rate of occurrence of the medullary type of differentiated or poorly differentiated adenocarcinoma were high and that there were relatively frequent invasion by cancerous cells of the blood vessel that were closely related to the hematogenous metastasis. On the other hand, with respect to recurrence of gastric cancer that had developed in the lung or bone, Borrmann type 3 and 4, respectively, were more frequently observed. In these cases, microscopic analysis revealed that these cancers were poorly differentiated adenocarcinomas. In gastric cancer with bone recurrence, the rate of recurrence of the scirrhous type of tumor were higher than that of other types. It is important, for the management of patients after gastric cancer surgery, to predict possible hematogenous recurrence and its site by evaluation of the pathologic characteristics of the gastric cancer.
对57例血行复发的胃癌患者，按复发部位对其病理特征进行了病理分析。在发生于肝脏的胃癌复发中，宏观观察显示，Borrmann 2型和3型癌最为常见。显微镜检查显示，高分化或低分化髓样腺癌的发生率较高，且与血行转移密切相关的癌细胞血管浸润相对频繁。另一方面，对于发生于肺或骨的胃癌复发，分别更常观察到Borrmann 3型和4型。在这些病例中，显微镜分析显示这些癌症为低分化腺癌。在骨复发的胃癌中，硬癌型肿瘤的复发率高于其他类型。通过评估胃癌的病理特征来预测可能的血行复发及其部位，对胃癌手术后患者的管理很重要。
