Theis J H, Lee G, Chan M C, Ikeda R M, Lee M H, Rink J L, Steffey E P, Thomas W P, Mason D T
School of Medicine, University of California, Davis 95616.
Lasers Surg Med. 1987;7(5):414-20. doi: 10.1002/lsm.1900070507.
A steerable, fiberoptic catheter coupled to a laser light guide tipped with a metal cap was used. Four monkeys fed an atherogenic diet for 7-8 years were angiographed and were found to have extensive mural plaque in the iliac arteries. Plaque sites in these monkeys were vaporized using the laser-heated metal cap. Energies of 1.5-9 Joules were employed. Application of the energy was tangential of perpendicular to the plaque. Lased sites were examined histologically at 24 hr or at 3 months after treatment. No effect was seen at 1.5 Joules. Three to six Joules tangentially produced a superficial lesion that extended into the tunica intima. Six Joules perpendicularly produced a burn into the tunica adventitia, with damage to the vasavasorum. Nine Joules tangentially produced a burn into the tunica media. Three months after treatment, this lased site showed no stenosis or aneurysm formation.
使用了一种可操纵的光纤导管，该导管与末端带有金属帽的激光光导相连。对4只喂食致动脉粥样化饮食7 - 8年的猴子进行血管造影，发现它们的髂动脉有广泛的壁内斑块。使用激光加热的金属帽将这些猴子斑块部位汽化。采用1.5 - 9焦耳的能量。能量施加方向与斑块垂直或相切。在治疗后24小时或3个月对激光照射部位进行组织学检查。1.5焦耳能量时未见效果。相切方向施加3至6焦耳能量产生了一个延伸至内膜的浅表损伤。垂直方向施加6焦耳能量导致外膜烧伤，并损伤了血管滋养管。相切方向施加9焦耳能量导致中膜烧伤。治疗3个月后，该激光照射部位未出现狭窄或动脉瘤形成。
