Mallahzadeh Arashk, Shafie Mahan, Tahvilian Mahdi, Sadeghi Mohammad, Moslemian Golsa, Barzin Pouria, Bemanalizadeh Maryam, Mayeli Mahsa, Aarabi Mohammad Hadi
NeuroTRACT Association, Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
NeuroTRACT Association, Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
J Affect Disord. 2023 Jun 15;331:251-258. doi: 10.1016/j.jad.2023.03.070. Epub 2023 Mar 22.
Reinforcement sensitivity theory (RST) is proposed as a neurobiological system that eventually led to emotion and motivation-based constructs of personality. Traditionally segmented into the behavioral activation system (BAS) and the behavioral inhibition system (BIS), RST is commonly used to describe personality and behavior. Although there have been studies linking gray matter alterations with BIS/BAS subscales, the role of white matter (WM) alterations is yet controversial. We aimed to investigate the specific WM tracts associated with BIS/BAS scores.
220 healthy participants (mean age = 39.14 ± 20.23, 80 (35.7 %) females) were evaluated using the BIS/BAS questionnaire from the LEMON database. Diffusion MRI connectometry (DMRI) was used to investigate the WM correlates of BIS/BAS subscales in each gender group. Multiple regression models with the covariates of age, handedness, and education were fitted to address the correlation of local connectomes with BIS/BAS components.
DMRI connectometry revealed that the quantitative anisotropy (QA) value of the splenium of the corpus callosum, right cerebellum, middle cerebellar peduncle, and superior cerebellar peduncle, had a significant negative correlation with each BIS/BAS subscale. In contrast, the QA value in the body of the corpus callosum and bilateral cingulum showed a positive correlation with BIS/BAS subscales.
The integrity of WM in certain tracts is associated with behavioral activation and inhibition. This finding expands our knowledge of the neural networks associated with risk-taking and reward-seeking behaviors.
强化敏感性理论（RST）被提出作为一种神经生物学系统，最终导致基于情感和动机的人格结构。传统上分为行为激活系统（BAS）和行为抑制系统（BIS），RST常用于描述人格和行为。尽管已有研究将灰质改变与BIS/BAS分量表联系起来，但白质（WM）改变的作用仍存在争议。我们旨在研究与BIS/BAS评分相关的特定白质束。
使用来自LEMON数据库的BIS/BAS问卷对220名健康参与者（平均年龄=39.14±20.23，80名（35.7%）女性）进行评估。采用扩散磁共振成像连接ometry（DMRI）研究每个性别组中BIS/BAS分量表的白质相关性。拟合具有年龄、利手和教育程度协变量的多元回归模型，以探讨局部连接组与BIS/BAS成分的相关性。
DMRI连接ometry显示，胼胝体压部、右侧小脑、小脑中脚和小脑上脚的定量各向异性（QA）值与每个BIS/BAS分量表均呈显著负相关。相反，胼胝体体部和双侧扣带的QA值与BIS/BAS分量表呈正相关。
某些白质束的完整性与行为激活和抑制有关。这一发现扩展了我们对与冒险和寻求奖励行为相关的神经网络的认识。
