Asirvatham S, Sebastian C, Thadani U
Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA.
Am J Gastroenterol. 1998 Mar;93(3):470-1. doi: 10.1111/j.1572-0241.1998.468_2.x.
A 29-yr-old white woman was hospitalized with bloody diarrhea secondary to ulcerative colitis. Within 24 h of receiving intravenous steroids, loperamide, and mesalamine, she developed symptomatic hypotension, severe sinus bradycardia, sinus pauses, and junctional escape beats. The hypotension and sinus bradycardia resolved after discontinuing mesalamine. She had a family history of conduction tissue disease but her exercise ECG and Holter studies were normal. She was rehospitalized 6 wk later with an exacerbation of ulcerative colitis and, within 8 h of receiving mesalamine, developed hypotension and severe sinus bradycardia, which resolved after stopping mesalamine. Thus mesalamine should be used with caution, especially in patients predisposed to cardiac conduction tissue disease.
一名29岁的白人女性因溃疡性结肠炎继发血性腹泻入院。在接受静脉注射类固醇、洛哌丁胺和美沙拉嗪后24小时内，她出现了症状性低血压、严重窦性心动过缓、窦性停搏和交界性逸搏。停用美沙拉嗪后，低血压和窦性心动过缓得到缓解。她有传导组织疾病家族史，但运动心电图和动态心电图检查正常。6周后，她因溃疡性结肠炎加重再次入院，在接受美沙拉嗪8小时内出现低血压和严重窦性心动过缓，停用美沙拉嗪后症状缓解。因此，使用美沙拉嗪应谨慎，尤其是对于有心脏传导组织疾病倾向的患者。
