Department of Immunology, Duke University School of Medicine, Durham, NC, USA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
Trends Cell Biol. 2023 Sep;33(9):803-815. doi: 10.1016/j.tcb.2023.02.008. Epub 2023 Mar 22.
Regulated cell death occurs in many forms, including apoptosis, pyroptosis, necroptosis, and NETosis. Most obviously, the purpose of these pathways is to kill the cell. However, many cells need to complete a set of effector programs before they die, which we define as a cellular 'bucket list'. These effector programs are specific to the cell type, and mode and circumstances of death. For example, intestinal epithelial cells need to complete the process of extrusion before they die. Cells use regulatory mechanisms to temporarily prolong their life, including endosomal sorting complex required for transport (ESCRT)- and acid sphingomyelinase (ASM)-driven membrane repair. These allow cells to complete their bucket lists before they die.
程序性细胞死亡有多种形式，包括细胞凋亡、细胞焦亡、细胞坏死和 NETosis。这些途径的最明显的目的是杀死细胞。然而，许多细胞在死亡之前需要完成一组效应器程序，我们将其定义为细胞的“遗愿清单”。这些效应器程序是细胞类型特异性的，并且与死亡的方式和情况有关。例如，肠上皮细胞在死亡之前需要完成挤出过程。细胞使用调节机制来暂时延长其寿命，包括内体分选复合物必需的运输 (ESCRT) 和酸性鞘磷脂酶 (ASM) 驱动的膜修复。这些机制允许细胞在死亡之前完成它们的“遗愿清单”。
