Oh Changhoon, Spears Todd J, Aachoui Youssef
Department of Microbiology and Immunology, Center for Microbial Pathogenesis and Host Responses, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Immunol Rev. 2025 Jan;329(1):e13408. doi: 10.1111/imr.13408. Epub 2024 Oct 15.
Macrophages, neutrophils, and epithelial cells are pivotal components of the host's immune response against bacterial infections. These cells employ inflammasomes to detect various microbial stimuli during infection, triggering an inflammatory response aimed at eradicating the pathogens. Among these inflammatory responses, pyroptosis, a lytic form of cell death, plays a crucial role in eliminating replicating bacteria and recruiting immune cells to combat the invading pathogen. The immunological function of pyroptosis varies across macrophages, neutrophils, and epithelial cells, aligning with their specific roles within the innate immune system. This review centers on elucidating the role of pyroptosis in resisting gram-negative bacterial infections, with a particular focus on the mechanisms at play in macrophages, neutrophils, and intestinal epithelial cells. Additionally, we underscore the cell type-specific roles of pyroptosis in vivo in these contexts during defense.
巨噬细胞、中性粒细胞和上皮细胞是宿主针对细菌感染的免疫反应的关键组成部分。这些细胞在感染过程中利用炎性小体来检测各种微生物刺激，引发旨在根除病原体的炎症反应。在这些炎症反应中，细胞焦亡作为一种细胞死亡的裂解形式，在消除正在复制的细菌和招募免疫细胞对抗入侵病原体方面发挥着关键作用。细胞焦亡的免疫功能在巨噬细胞、中性粒细胞和上皮细胞中各不相同，这与它们在固有免疫系统中的特定作用相一致。本综述聚焦于阐明细胞焦亡在抵抗革兰氏阴性菌感染中的作用，特别关注巨噬细胞、中性粒细胞和肠道上皮细胞中发挥作用的机制。此外，我们强调在这些情况下，细胞焦亡在体内防御过程中细胞类型特异性的作用。
