Jiang Yuan, Yuan Yi, Peng Feng, Deng Yi, Ren Chao, Liu Chongzhi, Dong Hai, Tu Tao
Clinical Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Department of Orthopedic, Dazhou Integrated TCM & Western Medicine Hospital, Dazhou Second People's Hospital, Dazhou, China.
Curr Drug Deliv. 2024;21(1):52-64. doi: 10.2174/1567201820666230320103529.
Erythrocytes are responsible for delivering oxygen throughout the body. They have become suitable drug carriers due to outstanding advantages, such as a long lifespan in circulation, high biosafety, and low immunogenicity. Although erythrocyte-based drug delivery has good application prospects and has become a research hotspot in related fields, the application of erythrocyte-based drug delivery systems is rare in the clinic now. In this review, we discuss the characteristics of erythrocytes, diverse drug-loading approaches, and research progress of erythrocyte-based drug delivery systems. Finally, we explore the challenges of erythrocyte-based drug delivery in clinical application.
红细胞负责将氧气输送到全身。由于具有诸如在循环中寿命长、生物安全性高和免疫原性低等突出优点，它们已成为合适的药物载体。尽管基于红细胞的药物递送具有良好的应用前景并已成为相关领域的研究热点，但目前基于红细胞的药物递送系统在临床上的应用却很少。在这篇综述中，我们讨论了红细胞的特性、多种载药方法以及基于红细胞的药物递送系统的研究进展。最后，我们探讨了基于红细胞的药物递送至临床应用中的挑战。
