Deschasaux-Tanguy Mélanie, Szabo de Edelenyi Fabien, Druesne-Pecollo Nathalie, Esseddik Younes, Allègre Julien, Srour Bernard, Galan Pilar, Hercberg Serge, Severi Gianluca, Zins Marie, Wiernik Emmanuel, de Lamballerie Xavier, Carrat Fabrice, Touvier Mathilde
Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center - Université Paris Cité (CRESS), Sorbonne Paris Nord University, Bobigny, France.
UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP UMR1018, Paris-Saclay University, Villejuif, France.
Sci Rep. 2023 Mar 23;13(1):4775. doi: 10.1038/s41598-023-30714-9.
ABO blood type has been reported as a potential factor influencing SARS-CoV-2 infection, but so far mostly in studies that involved small samples, selected population and/or used PCR test results. In contrast our study aimed to assess the association between ABO blood types and SARS-CoV-2 infection using seroprevalence data (independent of whether or not individuals had symptoms or sought for testing) in a large population-based sample. Our study included 67,340 French participants to the SAPRIS-SERO multi-cohort project. Anti-SARS-CoV-2 antibodies were detected using ELISA (targeting the proteins spike (S) and nucleocapsid (NP)) and seroneutralisation (SN) tests on dried blood spots collected in May-November 2020. Non-O individuals (and especially types A and AB) were more likely to bear anti SARS-CoV-2 antibodies (ELISA-S, 2964 positive cases: OR = 1.09[1.01-1.17], OR = 1.08[1.00-1.17]; ELISA-S/ELISA-NP/SN, 678 triple positive cases: OR = 1.19 [1.02-1.39], OR = 1.19[1.01-1.41], OR = 1.43[1.01-2.03]). Hence, our results provided additional insights into the dynamic of SARS-CoV-2 infection, highlighting a higher susceptibility of infection for individuals of blood types A and AB and a lesser risk for blood type O.
ABO血型被报道为影响新型冠状病毒感染的一个潜在因素，但到目前为止，大多是在涉及小样本、特定人群和/或使用PCR检测结果的研究中。相比之下，我们的研究旨在利用基于大样本人群的血清流行率数据（独立于个体是否有症状或寻求检测）来评估ABO血型与新型冠状病毒感染之间的关联。我们的研究纳入了参与SAPRIS-SERO多队列项目的67340名法国参与者。使用ELISA（针对刺突蛋白（S）和核衣壳蛋白（NP））以及对2020年5月至11月采集的干血斑进行血清中和（SN）试验来检测抗新型冠状病毒抗体。非O型个体（尤其是A型和AB型）更有可能携带抗新型冠状病毒抗体（ELISA-S检测，2964例阳性病例：OR = 1.09[1.01 - 1.17]，OR = 1.08[1.00 - 1.17]；ELISA-S/ELISA-NP/SN检测，678例三阳性病例：OR = 1.19 [1.02 - 1.39]，OR = 1.19[1.01 - 1.41]，OR = 1.43[1.01 - 2.03]）。因此，我们的结果为新型冠状病毒感染的动态变化提供了更多见解，突出了A型和AB型血个体感染的易感性更高，而O型血个体感染风险较低。
