Banchelli Federico, Negro Pierpaolo, Guido Marcello, D'Amico Roberto, Fittipaldo Veronica Andrea, Grima Pierfrancesco, Zizza Antonella
Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy.
Unit of Statistical and Methodological Support to Clinical Research, University Hospital of Modena, 41100 Modena, Italy.
J Clin Med. 2022 May 27;11(11):3029. doi: 10.3390/jcm11113029.
The SARS-CoV-2 infection has caused over 422 million contagions and 5.8 million deaths resulting in a global health crisis. Several studies have investigated the risk factors predisposing to the infection and reported that the host susceptibility can be linked to the ABO blood group, but the current evidence is controversial. We systematically searched for articles in EMBASE, PubMed, and Cochrane library published up to 7 May 2021 to explore the association of the ABO blood group with the susceptibility to SARS-CoV-2 infection. All studies in people undergoing SARS-CoV-2 test controls were included. Odds ratios were obtained in each study and then synthesised by using meta-analysis. Overall, 22 articles were selected and more than 1,200,000 individuals of whom 74,563 resulted positive to SARS-CoV-2 and 1,166,717 resulted negative, were included in the meta-analysis. Overall, 487,985 subjects had blood group A, 151,879 had group B, 52,621 had group AB, and 548,795 had group O. Group O was slightly less associated with infection, as compared to the other three blood groups (OR = 0.91, 95% CI = 0.85-0.99, = 0.02). Conversely, group A was slightly more associated with infection, as compared to the other three groups (OR = 1.06, 95% CI = 1.00-1.13, = 0.04). This meta-analysis shows associations between blood groups and SARS-CoV-2 infection and supports the hypothesis that blood type O may have a slightly lower risk of infection, whereas blood type A may have a slightly higher risk of infection.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染已导致超过4.22亿人感染，580万人死亡，引发了全球健康危机。多项研究调查了易感染该病毒的风险因素，并报告称宿主易感性可能与ABO血型有关，但目前的证据存在争议。我们系统检索了截至2021年5月7日在EMBASE、PubMed和Cochrane图书馆发表的文章，以探讨ABO血型与SARS-CoV-2感染易感性之间的关联。纳入了所有对接受SARS-CoV-2检测的人群进行对照研究的文献。在每项研究中获取比值比，然后通过荟萃分析进行综合。总体而言，共筛选出22篇文章，超过120万人纳入荟萃分析，其中74563人SARS-CoV-2检测呈阳性，1166717人呈阴性。总体而言，487985名受试者为A型血，151879名受试者为B型血，52621名受试者为AB型血，548795名受试者为O型血。与其他三种血型相比，O型血与感染的关联略低（比值比=0.91，95%置信区间=0.85-0.99，P=0.02）。相反，与其他三组相比，A型血与感染的关联略高（比值比=1.06，95%置信区间=1.00-1.13，P=0.04）。这项荟萃分析显示了血型与SARS-CoV-2感染之间的关联，并支持以下假设：O型血感染风险可能略低，而A型血感染风险可能略高。
