饮食模式与痴呆相关神经影像标志物之间的关联。

Associations between dietary patterns and dementia-related neuroimaging markers.

作者信息

Samuelsson Jessica, Marseglia Anna, Lindberg Olof, Westman Eric, Pereira Joana B, Shams Sara, Kern Silke, Ahlner Felicia, Rothenberg Elisabet, Skoog Ingmar, Zettergren Anna

机构信息

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP), University of Gothenburg, Mölndal, Sweden.

Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.

出版信息

Alzheimers Dement. 2023 Oct;19(10):4629-4640. doi: 10.1002/alz.13048. Epub 2023 Mar 24.

DOI:10.1002/alz.13048

PMID:36960849

Abstract

BACKGROUND

The exploration of associations between dietary patterns and dementia-related neuroimaging markers can provide insights on food combinations that may impact brain integrity.

METHODS

Data were derived from the Swedish Gothenburg H70 Birth Cohort Study (n = 610). Three dietary patterns were obtained using principal component analysis. Magnetic resonance imaging markers included cortical thickness, an Alzheimer's disease (AD) signature score, small vessel disease, and white matter microstructural integrity. Adjusted linear/ordinal regression analyses were performed.

RESULTS

A high-protein and alcohol dietary pattern was negatively associated with cortical thickness in the whole brain (Beta: -0.011; 95% confidence interval [CI]: -0.018 to -0.003), and with an Alzheimer's disease cortical thickness signature score (Beta: -0.013; 95% CI: -0.024 to -0.001). A positive association was found between a Mediterranean-like dietary pattern and white matter microstructural integrity (Beta: 0.078; 95% CI: 0.002-0.154). No associations were found with a Western-like dietary pattern.

DISCUSSION

Dietary patterns may impact brain integrity through neurodegenerative and vascular pathways.

HIGHLIGHTS

Certain dietary patterns were associated with dementia-related neuroimaging markers. A Mediterranean dietary pattern was positively associated with white matter microstructure. A high-protein and alcohol pattern was negatively associated with cortical thickness.

摘要

背景

探索饮食模式与痴呆相关神经影像标志物之间的关联，可为可能影响脑完整性的食物组合提供见解。

方法

数据来自瑞典哥德堡H70出生队列研究（n = 610）。使用主成分分析获得三种饮食模式。磁共振成像标志物包括皮质厚度、阿尔茨海默病（AD）特征评分、小血管疾病和白质微结构完整性。进行了调整后的线性/有序回归分析。

结果

高蛋白和酒精饮食模式与全脑皮质厚度呈负相关（β：-0.011；95%置信区间[CI]：-0.018至-0.003），与阿尔茨海默病皮质厚度特征评分呈负相关（β：-0.013；95%CI：-0.024至-0.001）。发现类似地中海饮食模式与白质微结构完整性呈正相关（β：0.078；95%CI：0.002 - 0.154）。未发现与类似西方饮食模式有关联。