Charmine Pricilla, Venkatesan Vettriselvi, Geminiganesan Sangeetha, Ekambaram Sudha, Nammalwar B R, Parameswari R P, Mohana Priya C D
Faculty of Clinical Research, SRIHER, No.1 Ramachandra Nagar, Porur, Chennai, 600116, India.
Department of Human Genetics, SRIHER, No.1 Ramachandra Nagar, Porur, Chennai, 600116, India.
Int Urol Nephrol. 2025 May 6. doi: 10.1007/s11255-025-04546-7.
Nephrotic syndrome is a complex renal condition characterized by abnormal protein permeability into the urine space, leading to edema and renal failure. Recent research suggests that deregulation of microRNAs contributes to the pathogenesis of this disease. MicroRNAs are small, non-coding RNA molecules that regulate gene expression by binding to complementary messenger RNA sequences. In this study, we employed bioinformatics techniques to analyze microRNA expression in urine samples from nephrotic syndrome patients and healthy control participants. Our results revealed a significant disruption of microRNA expression profiles in patients with nephrotic syndrome, indicating that these microRNAs may play a crucial role in the disease. This study highlights the potential of urinary microRNAs as biomarkers for nephrotic syndrome and warrants further investigation into their functional significance in the disease pathogenesis.
肾病综合征是一种复杂的肾脏疾病，其特征是尿液空间中蛋白质通透性异常，导致水肿和肾衰竭。最近的研究表明，微小RNA的失调促成了这种疾病的发病机制。微小RNA是小的非编码RNA分子，通过与互补的信使RNA序列结合来调节基因表达。在本研究中，我们采用生物信息学技术分析肾病综合征患者和健康对照参与者尿液样本中的微小RNA表达。我们的结果显示，肾病综合征患者的微小RNA表达谱有显著破坏，表明这些微小RNA可能在该疾病中起关键作用。这项研究突出了尿液微小RNA作为肾病综合征生物标志物的潜力，并值得进一步研究它们在疾病发病机制中的功能意义。
