Potter Christina, Mullen Lucia, Ssendagire Steven, Wanyenze Rhoda K, Ario Alex Riolexus, Tuhebwe Doreen, Babirye Susan, Nuwematsiko Rebecca, Nuzzo Jennifer B
Johns Hopkins Center for Health Security, Baltimore, Maryland, United States of America.
Department of Environmental Health & Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
PLOS Glob Public Health. 2022 May 11;2(5):e0000428. doi: 10.1371/journal.pgph.0000428. eCollection 2022.
Uganda has engaged in numerous capacity building activities related to outbreak preparedness over the last two decades and initiated additional just-in-time preparedness activities after the declaration of the 2018-2020 Ebola Virus Disease (EVD) outbreak in eastern Democratic Republic of Congo (DRC). When Uganda faced importation events related to the DRC outbreak in June-August 2019, the country's ability to prevent sustained in-country transmission was attributed to these long-term investments in preparedness. In order to help prepare countries for similar future scenarios, this analysis reviewed evidence from Uganda's response to the June-August 2019 importation events to identify preparedness activities and capacities that may have enabled Uganda to identify and isolate infected individuals or otherwise prevent further transmission. Content from 143 grey literature documents gathered via targeted and systematic searches from June 6, 2019 to October 29, 2019 and six interviews of key informants were utilized to inform a framework evaluation tool developed for this study. A conceptual framework of Uganda's preparedness activities was developed and evaluated against timelines of Uganda's response activities to the June-August 2019 EVD importation events based on the applicability of a preparedness activity to a response activity and the contribution of the said response activity to the prevention or interruption of transmission. Preparedness activities related to coordination, health facility preparation, case referral and management, laboratory testing and specimen transport, logistics and resource mobilization, and safe and dignified burials yielded consistent success across both importation events while point of entry screening was successful in one importation event but not another according to the framework evaluation tool. Countries facing similar threats should consider investing in these preparedness areas. Future analyses should validate and expand on the use of the framework evaluation tool.
在过去二十年里,乌干达开展了许多与疫情防范相关的能力建设活动,并在2018 - 2020年刚果民主共和国东部埃博拉病毒病(EVD)疫情宣布后启动了额外的即时防范活动。2019年6月至8月乌干达面临与刚果民主共和国疫情相关的输入事件时,该国预防国内持续传播的能力归因于这些对防范的长期投资。为了帮助各国为未来类似情况做好准备,本分析回顾了乌干达应对2019年6月至8月输入事件的证据,以确定可能使乌干达能够识别和隔离感染者或以其他方式防止进一步传播的防范活动和能力。通过从2019年6月6日至2019年10月29日进行有针对性的系统搜索收集的143份灰色文献文件的内容以及对关键信息提供者的六次访谈,被用于为该研究开发的框架评估工具提供信息。根据防范活动对应对活动的适用性以及所述应对活动对预防或阻断传播的贡献,针对乌干达对2019年6月至8月埃博拉病毒病输入事件的应对活动时间表,制定并评估了乌干达防范活动的概念框架。与协调、医疗机构准备、病例转诊与管理、实验室检测与样本运输、后勤与资源调动以及安全体面埋葬相关的防范活动在两次输入事件中均取得了一致成功,而根据框架评估工具,入境点筛查在一次输入事件中成功,但在另一次输入事件中未成功。面临类似威胁的国家应考虑在这些防范领域进行投资。未来的分析应验证并扩展框架评估工具的使用。