Lu Tianyi, Chen Yaqian, Sun Meng, Chen Yuxian, Tu Weilong, Zhou Yuxuan, Li Xiao, Hu Tao
School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacturing of Precision Medicine Equipment, Southeast University, Nanjing 211189, China.
National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China.
Gels. 2025 May 6;11(5):345. doi: 10.3390/gels11050345.
Compared with acute wounds, typical chronic wounds (infection, burn, and diabetic wounds) are susceptible to bacterial infection and hard to heal. As for the complexity of chronic wounds, biocompatible hydrogel dressings can be employed to regulate the microenvironment and accelerate wound healing with their controllable physical and chemical properties. Recently, various nanomaterials have been introduced into hydrogel networks to prepare functional nanocomposite hydrogels. Among them, carbon-based nanomaterials (CBNs) have attracted wide attention in the biomedical field due to their outstanding physicochemical properties. However, comprehensive reviews on the use of CBNs for multifunctional hydrogel wound dressings in the past 10 years are very scarce. This review focuses on the research progress on hydrogel dressings made with typical CBNs. Specifically, a series of CBNs (carbon dots, graphene quantum dots, fullerenes, nanodiamonds, carbon nanotubes, graphene, graphene oxide and reduced graphene oxide) employed in the preparation of hydrogels are described as well as carbon-based nanocomposite hydrogels (CBNHs) with versatility (conductivity, antibacterial, injectable and self-healing, anti-inflammatory and antioxidant properties, substance delivery, stimulus response and real-time monitoring). Moreover, applications of CBNHs in treating different chronic wounds are concretely discussed. This review may provide some new inspirations for the future development of CBNHs in wound care and tissue engineering.
与急性伤口相比，典型的慢性伤口（感染性、烧伤性和糖尿病性伤口）易受细菌感染且难以愈合。鉴于慢性伤口的复杂性，可采用具有生物相容性的水凝胶敷料来调节微环境，并凭借其可控的物理和化学性质加速伤口愈合。近来，各种纳米材料已被引入水凝胶网络以制备功能性纳米复合水凝胶。其中，碳基纳米材料（CBNs）因其出色的物理化学性质在生物医学领域引起了广泛关注。然而，过去10年关于CBNs用于多功能水凝胶伤口敷料的综合综述非常匮乏。本综述聚焦于用典型CBNs制成的水凝胶敷料的研究进展。具体而言，描述了一系列用于制备水凝胶的CBNs（碳点、石墨烯量子点、富勒烯、纳米金刚石、碳纳米管、石墨烯、氧化石墨烯和还原氧化石墨烯）以及具有多功能性（导电性、抗菌性、可注射和自愈性、抗炎和抗氧化性能、物质递送、刺激响应和实时监测）的碳基纳米复合水凝胶（CBNHs）。此外，还具体讨论了CBNHs在治疗不同慢性伤口方面的应用。本综述可能为CBNHs在伤口护理和组织工程领域的未来发展提供一些新的启示。
