Department of Clinical Oncology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.
Sci Rep. 2023 Mar 24;13(1):4868. doi: 10.1038/s41598-023-32092-8.
Functional properties caused by TP53 mutations are involved in cancer development and progression. Although most of the mutations lose normal p53 functions, some of them, gain-of-function (GOF) mutations, exhibiting novel oncogenic functions. No reports have analyzed the impact of TP53 mutations on the gene expression profile of the p53 signaling pathway across cancer types. This study is a cross-cancer type analysis of the effects of TP53 mutations on gene expression. A hierarchical cluster analysis of the expression profile of the p53 signaling pathway classified 21 cancer types into two clusters (A1 and A2). Changes in the expression of cell cycle-related genes and MKI67 by TP53 mutations were greater in cluster A1 than in cluster A2. There was no distinct difference in the effects between GOF and non-GOF mutations on the gene expression profile of the p53 signaling pathway.
TP53 突变引起的功能特性与癌症的发生和发展有关。虽然大多数突变丧失了正常的 p53 功能，但其中一些获得功能（GOF）突变表现出新颖的致癌功能。目前还没有报道分析 TP53 突变对跨癌症类型的 p53 信号通路基因表达谱的影响。本研究对 TP53 突变对基因表达的影响进行了跨癌症类型的分析。p53 信号通路表达谱的层次聚类分析将 21 种癌症分为两个聚类（A1 和 A2）。与 A2 相比，A1 中细胞周期相关基因和 MKI67 的表达受 TP53 突变的影响更大。GOF 和非 GOF 突变对 p53 信号通路基因表达谱的影响之间没有明显的区别。
