Fast Program, Alexandra Hospital, National University Hospital System, Singapore.
Tumori. 2024 Feb;110(1):10-24. doi: 10.1177/03008916231158411. Epub 2023 Mar 24.
The cancer stem cell model hopes to explain solid tumour carcinogenesis, tumour progression and treatment failure in cancers. However, the cancer stem cell model has led to minimal clinical translation to cancer stem cell biomarkers and targeted therapies in solid tumours. Many reasons underlie the challenges, one being the imperfect understanding of the cancer stem cell model. This review hopes to spur further research into clinically translatable cancer stem cell biomarkers through first defining cancer stem cells and their associated models. With a better understanding of these models there would be a development of more accurate biomarkers. Making the clinical translation of biomarkers into diagnostic tools and therapeutic agents more feasible.
癌症干细胞模型旨在解释实体瘤的癌变、肿瘤进展和治疗失败。然而，癌症干细胞模型在实体瘤的癌症干细胞生物标志物和靶向治疗方面的临床转化很少。导致这种情况的原因有很多，其中一个原因是对癌症干细胞模型的理解并不完善。本文希望通过首先定义癌症干细胞及其相关模型，来激发对临床可转化的癌症干细胞生物标志物的进一步研究。通过更好地了解这些模型，将开发出更准确的生物标志物。使生物标志物的临床转化为诊断工具和治疗剂更加可行。
