Fetomaternal Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Obstetrics and Gynecology Department, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Clin Transl Oncol. 2023 Oct;25(10):2783-2792. doi: 10.1007/s12094-023-03148-y. Epub 2023 Mar 25.
Ovarian cancer (OC) is the most deadly tumor that may develop in a woman's reproductive system. It is also one of the most common causes of death among those who have been diagnosed with cancer in women. An adapter protein known as sequestosome 1(SQSTM1) or p62 is primarily responsible for the transportation, degradation, and destruction of a wide variety of proteins. This adapter protein works in conjunction with the autophagy process as well as the ubiquitin proteasome degradation pathway. In addition, the ability of SQSTM1 to interact with multiple binding partners link SQSTM1 to various pathways in the context of antioxidant defense system and inflammation. In this review, we outline the processes underlying the control that SQSTM1 has on these pathways and how their dysregulation contributes to the development of OC. At the final, the therapeutic approaches based on SQSTM1 targeting have been discussed.
卵巢癌（OC）是女性生殖系统中最致命的肿瘤之一。它也是女性癌症患者死亡的最常见原因之一。一种称为自噬相关蛋白 1（SQSTM1）或 p62 的衔接蛋白主要负责多种蛋白质的运输、降解和破坏。这种衔接蛋白与自噬过程以及泛素蛋白酶体降解途径协同作用。此外，SQSTM1 与多种结合伴侣相互作用的能力将 SQSTM1 与抗氧化防御系统和炎症中的各种途径联系起来。在这篇综述中，我们概述了 SQSTM1 对这些途径的控制过程，以及它们的失调如何导致 OC 的发展。最后，讨论了基于 SQSTM1 靶向的治疗方法。
