儿童患者的涎腺上皮性肿瘤：一项国际合作研究。

Epithelial salivary gland tumors in pediatric patients: An international collaborative study.

作者信息

Quixabeira Oliveira Gabriella Alves, Pérez-DE-Oliveira Maria Eduarda, Robinson Liam, Khurram Syed Ali, Hunter Keith, Speight Paul M, Kowalski Luiz Paulo, Lopes Pinto Clóvis Antonio, Sales De Sá Raísa, Mendonça Elismauro Francisco, Sousa-Neto Sebastião Silvério, de Carlucci Junior Dorival, Mariano Fernanda Viviane, Altemani Albina Messias de Almeida Milani, Martins Manoela Domingues, Zanella Virgílio Gonzales, Perez Danyel Elias da Cruz, Dos Santos Jean Nunes, Romañach Mário José, Abrahão Aline Corrêa, Andrade Bruno Augusto Benevenuto de, Pontes Hélder Antônio Rebelo, Jorge Junior Jacks, Santos-Silva Alan Roger, Lopes Márcio Ajudarte, Van Heerden Willie F P, Vargas Pablo Agustin

机构信息

Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.

Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

出版信息

Int J Pediatr Otorhinolaryngol. 2023 May;168:111519. doi: 10.1016/j.ijporl.2023.111519. Epub 2023 Mar 21.

DOI:10.1016/j.ijporl.2023.111519

PMID:36965251

Abstract

OBJECTIVE

Salivary gland tumors (SGT) are a diverse group of uncommon neoplasms that are rare in pediatric patients. This study aimed to characterize the clinicopathological profile of pediatric patients affected by SGT from a large case series derived from an international group of academic centers.

STUDY DESIGN

A retrospective analysis of pediatric patients with SGT (0-19 years old) diagnosed between 2000 and 2021 from Brazil, South Africa, and the United Kingdom was performed. SPSS Statistics for Windows was used for a quantitative analysis of the data, with a descriptive analysis of the clinicopathological characteristics and the association between clinical variables and diagnoses.

RESULTS

A total of 203 cases of epithelial SGT were included. Females were slightly more commonly (56.5%), with a mean age of 14.1 years. The palate was the most common site (43.5%), followed by the parotid gland (29%), lip (10%), and submandibular gland (7.5%). The predominant clinical presentation was a flesh-colored, smooth, and painless nodule. Pleomorphic adenoma (PA) was the most frequently diagnosed SGT (58.6%), followed by mucoepidermoid carcinoma (MEC) (26.6%). Surgery (90.8%) was the favored treatment option.

CONCLUSIONS

Benign SGT in pediatric patients are more commonly benign than malignant tumors. Clinicians should keep PA and MEC in mind when assessing nodular lesions of possible salivary gland origin in pediatric patients.

摘要

目的

涎腺肿瘤（SGT）是一组多样的罕见肿瘤，在儿科患者中较为少见。本研究旨在通过一个来自国际学术中心团队的大型病例系列，描述受SGT影响的儿科患者的临床病理特征。

研究设计

对2000年至2021年间在巴西、南非和英国诊断出的SGT儿科患者（0至19岁）进行回顾性分析。使用SPSS for Windows统计软件对数据进行定量分析，对临床病理特征以及临床变量与诊断之间的关联进行描述性分析。

结果

共纳入203例上皮性SGT病例。女性略多（56.5%），平均年龄为14.1岁。腭部是最常见的部位（43.5%），其次是腮腺（29%）、唇部（10%）和下颌下腺（7.5%）。主要临床表现为肉色、光滑、无痛性结节。多形性腺瘤（PA）是最常诊断出的SGT（58.6%），其次是黏液表皮样癌（MEC）（26.6%）。手术（90.8%）是首选的治疗方案。