He Lu-Xi, He Liang-Ying, Gao Fang-Zhou, Zhang Min, Chen Jun, Jia Wei-Li, Ye Pu, Jia Yu-Wei, Hong Bai, Liu Si-Si, Liu You-Sheng, Zhao Jian-Liang, Ying Guang-Guo
SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China.
SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China.
J Hazard Mater. 2023 Jun 15;452:131208. doi: 10.1016/j.jhazmat.2023.131208. Epub 2023 Mar 16.
Antibiotics are increasingly used and released into the marine environment due to the rapid development of mariculture, resulting in spread of antibiotic resistance. The pollution, distribution, and characteristics of antibiotics, antibiotic resistance genes (ARGs) and microbiomes have been investigated in this study. Results showed that 20 antibiotics were detected in Chinese coastal environment, with predominance of erythromycin-HO, enrofloxacin and oxytetracycline. In coastal mariculture sites, antibiotic concentrations were significantly higher than in control sites, and more types of antibiotics were detected in the South than in the North of China. Residues of enrofloxacin, ciprofloxacin and sulfadiazine posed high resistance selection risks. β-Lactam, multi-drug and tetracycline resistance genes were frequently detected with significantly higher abundance in the mariculture sites. Of the 262 detected ARGs, 10, 26, and 19 were ranked as high-risk, current-risk, future-risk, respectively. The main bacterial phyla were Proteobacteria and Bacteroidetes, of which 25 genera were zoonotic pathogens, with Arcobacter and Vibrio in particular ranking in the top10. Opportunistic pathogens were more widely distributed in the northern mariculture sites. Phyla of Proteobacteria and Bacteroidetes were the potential hosts of high-risk ARGs, while the conditional pathogens were associated with future-risk ARGs, indicating a potential threat to human health.
由于海水养殖的快速发展，抗生素在海洋环境中的使用和排放日益增加，导致抗生素耐药性的传播。本研究调查了抗生素、抗生素耐药基因（ARGs）和微生物群落的污染、分布及特征。结果表明，在中国沿海环境中检测到20种抗生素，其中红霉素-HO、恩诺沙星和土霉素占主导地位。在沿海海水养殖场所，抗生素浓度显著高于对照场所，且在中国南方检测到的抗生素种类比北方更多。恩诺沙星、环丙沙星和磺胺嘧啶的残留具有较高的耐药性选择风险。β-内酰胺、多药和四环素耐药基因经常被检测到，且在海水养殖场所中的丰度显著更高。在检测到的262种ARGs中，分别有10种、26种和19种被列为高风险、当前风险和未来风险。主要细菌门类为变形菌门和拟杆菌门，其中25个属为人畜共患病原体，特别是弓形杆菌属和弧菌属位列前十。机会性病原体在北方海水养殖场所分布更为广泛。变形菌门和拟杆菌门是高风险ARGs的潜在宿主，而条件性病原体与未来风险ARGs相关，这表明对人类健康存在潜在威胁。
