关于泪膜稳定性的新假说。
A new hypothesis on tear film stability.
作者信息
Liotet S, Van Bijsterveld O P, Kogbe O, Laroche L
机构信息
Hôpital des Quinze-Vingts, Paris, France.
出版信息
Ophthalmologica. 1987;195(3):119-24. doi: 10.1159/000309798.
Classically, the stability of the lacrimal film is due to the surfacing of the epithelial surface by the mucus produced by the goblet cells. However, there are many objections to this hypothesis. Deducing from electron microscopy of the epithelial cells, which shows vesicles in the superficial layer and glycocalix threads on the microvilli and other clinical facts, we think that the surfacing agent is not mucus but glycocalix. The disappearance of goblet cells during sicca syndrome is not the cause but the result of the dryness. Epithelial cell integrity is essential for the stability of the tear film and therapeutics must aim at regenerating these cells rather than only replacing the lacrimal film by tear substitute.
传统上，泪膜的稳定性归因于杯状细胞产生的黏液覆盖上皮表面。然而，这一假说存在诸多问题。从上皮细胞的电子显微镜观察结果来看，表层有小泡，微绒毛上有糖萼丝，结合其他临床事实，我们认为覆盖剂不是黏液而是糖萼。干燥综合征期间杯状细胞的消失不是干眼症的病因而是结果。上皮细胞的完整性对泪膜的稳定性至关重要，治疗必须旨在使这些细胞再生，而不是仅用人工泪液替代泪膜。
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