Petersen Christian P
Department of Molecular Biosciences, Northwestern University, Evanston, IL, United States; Robert Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL, United States.
Curr Top Dev Biol. 2023;153:347-380. doi: 10.1016/bs.ctdb.2023.01.007. Epub 2023 Mar 8.
Regeneration abilities are widespread among animals and select species can restore any body parts removed by wounds that sever the major body axes. This capability of whole-body regeneration as exemplified in flatworm planarians, Acoels, and Cnidarians involves initial responses to injury, the assessment of wound site polarization, determination of missing tissue and programming of blastema fate, and patterned outgrowth to restore axis content and proportionality. Wnt signaling drives many shared and conserved aspects of the biology of whole-body regeneration in the planarian species Schmidtea mediterranea and Dugesia japonica, in the Acoel Hofstenia miamia, and in Cnidarians Hydra and Nematostella. These overlapping mechanisms suggest whole-body regeneration might be an ancestral property across diverse animal taxa.
再生能力在动物中广泛存在，某些特定物种能够修复因切断主要体轴的伤口而移除的任何身体部位。扁形动物涡虫、无肠目动物和刺胞动物所展现的这种全身再生能力，涉及对损伤的初始反应、伤口部位极化的评估、缺失组织的确定以及芽基命运的编程，还有恢复体轴内容和比例的模式化生长。在真涡虫属的地中海涡虫和日本三角涡虫、无肠目动物迈阿密霍夫stenia、刺胞动物水螅和星状海葵中，Wnt信号传导驱动了全身再生生物学的许多共同且保守的方面。这些重叠的机制表明，全身再生可能是不同动物类群的一种原始特性。
