The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China.
Department of Chemistry and Biochemistry, University of Texas at El Paso, 500 West University Ave, El Paso, TX 79968, USA.
Trends Biotechnol. 2023 Aug;41(8):1055-1065. doi: 10.1016/j.tibtech.2023.03.005. Epub 2023 Mar 25.
Biosensors that sense the concentration of a specified target and produce a specific signal output have become important technology for biological analysis. Recently, intelligent biosensors have received great interest due to their adaptability to meet sophisticated demands. Advances in developing standard modules and carriers in synthetic biology have shed light on intelligent biosensors that can implement advanced analytical processing to better accommodate practical applications. This review focuses on intelligent synthetic biology-enabled biosensors (SBBs). First, we illustrate recent progress in intelligent SBBs with the capability of computation, memory storage, and self-calibration. Then, we discuss emerging applications of SBBs in point-of-care testing (POCT) and wearable monitoring. Finally, future perspectives on intelligent SBBs are proposed.
生物传感器能够感知特定目标的浓度并产生特定的信号输出，已成为生物分析的重要技术。最近，由于其适应复杂需求的能力，智能生物传感器受到了极大的关注。合成生物学中标准模块和载体的发展进步为能够实现先进分析处理以更好地适应实际应用的智能生物传感器提供了思路。本文主要关注智能合成生物学赋能的生物传感器（SBBs）。首先，我们阐述了具有计算、存储和自校准能力的智能 SBBs 的最新进展。然后，我们讨论了 SBBs 在即时检测（POCT）和可穿戴监测中的新兴应用。最后，我们提出了对智能 SBBs 的未来展望。
