Esfandiari Amir Hossein, Farkhani Hadis Hajipir, Javan Zahra Hashemi, Vojdani Arastoo, Velayati Mahla, Mahaki Hanie, Meshkat Zahra, Manoochehri Hamed, Avan Amir, Tanzadehpanah Hamid
Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Paramedical Sciences, Islamic Azad University of Mashhad, Mashhad, Iran.
Curr Med Chem. 2025;32(23):4725-4741. doi: 10.2174/0109298673295474240531100312.
Hepatitis B is still one of the most important infectious diseases among humans, which is considered a serious threat to their lives. Early diagnosis of this disease can be an effective measure in stopping the chain of transmission and treatment of the disease. In this review study, an attempt has been made to explain the use of biosensors as a fast, high-efficiency, and low-cost method in diagnosis. The biosensors prepared for hepatitis detection included DNA-based, aptamers-based, protein-based, enzyme-based, antibody-based, and polymers-based biosensors, each of which had different advantages. The results of this review showed that almost all introduced biosensors had an acceptable performance. However, we suggest that aptamers are desirable for biosensing applications because they can change their structure to properly bind to their target, are cost-effective to prepare, and are highly sensitive.
乙型肝炎仍然是人类最重要的传染病之一，被认为对人类生命构成严重威胁。该疾病的早期诊断是阻断传播链和治疗疾病的有效措施。在本综述研究中，已尝试解释生物传感器作为一种快速、高效且低成本的诊断方法的应用。用于肝炎检测的生物传感器包括基于DNA的、基于适配体的、基于蛋白质的、基于酶的、基于抗体的和基于聚合物的生物传感器，每种都有不同的优点。本综述结果表明，几乎所有引入的生物传感器都具有可接受的性能。然而，我们建议适配体适用于生物传感应用，因为它们可以改变其结构以与靶标正确结合，制备成本效益高且高度灵敏。
