Kapadia S B
Cancer. 1979 Feb;43(2):435-9. doi: 10.1002/1097-0142(197902)43:2<435::aid-cncr2820430205>3.0.co;2-g.
Histiocytic lymphoma of the ileocecal region developed in a patient with multiple myeloma following successful long-term alkylating agent therapy. Five and one-half years after the diagnosis of myeloma, while in remission on cyclophosphamide therapy, the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma. A right hemicolectomy was performed with relief of symptoms. However, 9 months later, while still asymptomatic, routine physical examination revealed a recurrent right lower quadrant tumor. Radiation therapy decreased the size of the mass, but five months later partial small bowel obstruction occurred because of recurrent lymphomatous infiltration. The patient died 7 years after the diagnosis of myeloma with extensive abdominal lymphoma. There was no evidence of recurrent myeloma after the initial remission on cyclophosphamide therapy. This patient adds to the growing literature of a second malignancy occurring after prolonged successful chemotherapy of a primary neoplasm.
一名患有多发性骨髓瘤的患者在长期成功接受烷化剂治疗后，发生了回盲部组织细胞性淋巴瘤。骨髓瘤诊断五年半后，患者在接受环磷酰胺治疗处于缓解期时，因巨大的盲肠淋巴瘤出现严重的右下腹疼痛。行右半结肠切除术，症状缓解。然而，9个月后，尽管仍无症状，但常规体格检查发现右下腹肿瘤复发。放射治疗使肿块缩小，但5个月后因淋巴瘤复发浸润导致部分小肠梗阻。该患者在骨髓瘤诊断7年后死于广泛的腹部淋巴瘤。在环磷酰胺治疗初始缓解后，没有骨髓瘤复发的证据。该患者补充了原发性肿瘤长期成功化疗后发生第二种恶性肿瘤的文献资料。
