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Live or let die: Translational insights and clinical perspectives of gasdermin B-dependent intestinal epithelial cell fate.

作者信息

Privitera Giuseppe, Pizarro Theresa T

机构信息

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

出版信息

Clin Transl Med. 2022 Apr;12(4):e787. doi: 10.1002/ctm2.787.

DOI:10.1002/ctm2.787
PMID:35485236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9052010/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820a/9052010/b7d86138fee6/CTM2-12-e787-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820a/9052010/b7d86138fee6/CTM2-12-e787-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820a/9052010/b7d86138fee6/CTM2-12-e787-g001.jpg

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本文引用的文献

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Novel Insights Into the Interactions Between the Gut Microbiome, Inflammasomes, and Gasdermins During Colorectal Cancer.肠道微生物组、炎性体和 Gasdermins 在结直肠癌中的相互作用的新见解。
Front Cell Infect Microbiol. 2022 Jan 17;11:806680. doi: 10.3389/fcimb.2021.806680. eCollection 2021.
2
GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis.GSDMB 在 IBD 中增加,并独立于细胞焦亡调节上皮修复/再生。
Cell. 2022 Jan 20;185(2):283-298.e17. doi: 10.1016/j.cell.2021.12.024. Epub 2022 Jan 11.
3
Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions.
上皮型 Gasdermin B 的神秘角色:最新发现与争议。
Trends Cell Biol. 2023 Jan;33(1):48-59. doi: 10.1016/j.tcb.2022.06.006. Epub 2022 Jul 9.
GSDMB 的致病性泛素化抑制 NK 细胞的杀菌功能。
Cell. 2021 Jun 10;184(12):3178-3191.e18. doi: 10.1016/j.cell.2021.04.036. Epub 2021 May 21.
4
The human tumor microbiome is composed of tumor type-specific intracellular bacteria.人类肿瘤微生物组由肿瘤类型特异性的内共生细菌组成。
Science. 2020 May 29;368(6494):973-980. doi: 10.1126/science.aay9189.
5
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.细胞毒性淋巴细胞中的颗粒酶 A 裂解 GSDMB 以在靶细胞中引发细胞焦亡。
Science. 2020 May 29;368(6494). doi: 10.1126/science.aaz7548. Epub 2020 Apr 16.
6
Methotrexate and its mechanisms of action in inflammatory arthritis.甲氨蝶呤及其在炎症性关节炎中的作用机制。
Nat Rev Rheumatol. 2020 Mar;16(3):145-154. doi: 10.1038/s41584-020-0373-9. Epub 2020 Feb 17.
7
The gasdermins, a protein family executing cell death and inflammation.gasdermins,一个执行细胞死亡和炎症的蛋白家族。
Nat Rev Immunol. 2020 Mar;20(3):143-157. doi: 10.1038/s41577-019-0228-2. Epub 2019 Nov 5.
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Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death.gasdermin 家族驱动细胞焦亡的结构见解
Adv Exp Med Biol. 2019;1172:189-205. doi: 10.1007/978-981-13-9367-9_9.
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