Wong Stephanie, Safaeian Romina, Zobel Joshua, Holloway Richard H, Ruszkiewicz Andrew, Nguyen Nam Q
Department of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia Australia.
School of Medicine University of Adelaide Adelaide South Australia Australia.
JGH Open. 2023 Feb 1;7(3):178-181. doi: 10.1002/jgh3.12866. eCollection 2023 Mar.
Eosinophilic esophagitis (EoE) is a chronic disease which may progress to a fibro-stenotic phenotype due to esophageal sub-epithelial fibrosis. Esophageal wall thickening in patients with EoE has been demonstrated in a few studies using endoscopic ultrasound (EUS). The aim of this study was to longitudinally assess the endoscopic appearance, wall thickness, histology, and dysphagia score of EoE patients.
Patients with EoE were recruited and studied between February 2012 and April 2021. Patients were evaluated on two separate occasions at least 12 months apart with endoscopy, EUS, and esophageal mucosal biopsies. The dysphagia score and epidemiology data were also assessed.
A total of 16 EoE patients were included with a mean follow-up duration of 2.2 ± 1.2 years. In 14/16 (88%) patients, the total wall thickness of the distal esophagus significantly increased ( = 0.0012) as a result of thickening of the muscularis propria ( = 0.0218). However, only 1/14 (7%) patient had an increase in the dysphagia score, while 8/14 (57%) and 5/14 (36%) had a stable and reduced dysphagia score, respectively. No differences were found in the total thickness of other esophageal regions, dysphagia score, endoscopic appearance, and eosinophil count over time.
Distal esophageal wall thickness increases with time in EoE patients, independent of the dysphagia score and eosinophil count.
嗜酸性粒细胞性食管炎（EoE）是一种慢性疾病，由于食管上皮下纤维化，可能进展为纤维狭窄型。少数研究使用内镜超声（EUS）证实了EoE患者的食管壁增厚。本研究的目的是纵向评估EoE患者的内镜表现、壁厚度、组织学和吞咽困难评分。
2012年2月至2021年4月招募并研究了EoE患者。患者至少间隔12个月接受两次独立的内镜检查、EUS检查和食管黏膜活检评估。还评估了吞咽困难评分和流行病学数据。
共纳入16例EoE患者，平均随访时间为2.2±1.2年。在14/16（88%）的患者中，由于固有肌层增厚（P=0.0218），食管远端的总壁厚度显著增加（P=0.0012）。然而，只有1/14（7%）的患者吞咽困难评分增加，而8/14（57%）和5/14（36%）的患者吞咽困难评分分别保持稳定和降低。随着时间的推移，其他食管区域的总厚度、吞咽困难评分、内镜表现和嗜酸性粒细胞计数均未发现差异。
EoE患者食管远端壁厚度随时间增加，与吞咽困难评分和嗜酸性粒细胞计数无关。
