牙周病与 COVID-19：发病机制中预后及潜在关联途径。
Periodontal disease and COVID-19: Prognosis and potential pathways of association in their pathogenesis.
机构信息
Alumna, University of Cuenca, Cuenca, Ecuador.
Professor, University of Cuenca, Cuenca, Ecuador.
出版信息
Can J Dent Hyg. 2023 Feb 1;57(1):44-51. eCollection 2023 Feb.
OBJECTIVE
The objective of this narrative review is to determine if periodontal disease is a factor in the development of a poor prognosis for COVID-19.
METHOD
A bibliographic search was conducted in PubMed, Virtual Health Library, Google Scholar, and in the databases of Science Direct, Scopus, Lilacs, Bireme, Scielo, and Web of Science, using the following keywords: "COVID-19," "SARS-CoV-2," and "periodontal diseases."
RESULTS
Fifty-six records were retrieved from the database searches. After screening, 39 articles were selected for study: 13 reviews, 2 case-control studies, 1 systematic review, 8 letters to the editor, 2 cohort studies, 1 thesis, 7 hypotheses, 1 short communication, 3 commentaries, and 1 scoping review.
DISCUSSION
Both periodontal disease and COVID-19 produce an inflammatory response. This immune response generates an over-production of inflammatory cytokines that can harm overall health.
CONCLUSION
The mouth serves as the entryway for many microorganisms that can harm health in general, among them SARS-CoV-2. It is important to maintain good oral health to lower the inflammatory load present in periodontal disease, lessening the possibility of complications from COVID-19.
目的
本叙述性综述旨在确定牙周病是否是 COVID-19 预后不良的一个因素。
方法
在 PubMed、Virtual Health Library、Google Scholar 以及 Science Direct、Scopus、Lilacs、Bireme、Scielo 和 Web of Science 数据库中，使用以下关键词进行文献检索：“COVID-19”、“SARS-CoV-2”和“牙周病”。
结果
从数据库检索中检索到 56 条记录。经过筛选，选择了 39 篇文章进行研究：13 篇综述、2 篇病例对照研究、1 篇系统评价、8 篇给编辑的信、2 篇队列研究、1 篇论文、7 个假设、1 篇短通讯、3 篇评论和 1 篇范围综述。
讨论
牙周病和 COVID-19 都会引起炎症反应。这种免疫反应会产生过多的炎症细胞因子，从而损害整体健康。
结论
口腔是许多微生物进入人体的入口，这些微生物会损害整体健康，其中包括 SARS-CoV-2。保持良好的口腔健康以降低牙周病中存在的炎症负担非常重要，这可以降低 COVID-19 并发症的可能性。
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