Vincent Jean-Louis
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Front Med (Lausanne). 2023 Mar 9;10:1156732. doi: 10.3389/fmed.2023.1156732. eCollection 2023.
The underlying cause of sepsis is a dysregulated host response to infection, leading to multiple organ failure. Identifying sepsis is crucial because of the associated pathophysiological, practical, and therapeutic implications, which will determine where and how the patient should be managed. In the absence of an end-of-life decision to limit therapies, the patient should be admitted to the intensive care unit immediately. Importantly, not all patients with sepsis are the same and being able to better characterize them is important. The future will focus on phenotypes to characterize critically ill patients, with or without infection, to enable more appropriate targeting of therapeutic interventions.
脓毒症的根本原因是宿主对感染的反应失调，进而导致多器官功能衰竭。由于脓毒症具有相关的病理生理、实际操作及治疗方面的影响，这些影响将决定患者的管理地点及方式，因此识别脓毒症至关重要。在没有限制治疗的临终决定的情况下，患者应立即入住重症监护病房。重要的是，并非所有脓毒症患者都相同，能够更好地对他们进行特征描述很重要。未来将聚焦于对危重症患者（无论有无感染）进行特征描述的表型，以便更精准地靶向治疗干预措施。
