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在阿富汗成年人中,多维贫困与痴呆症相关。

Multidimensional poverty is associated with dementia among adults in Afghanistan.

作者信息

Trani Jean-Francois, Zhu Yiqi, Park Soobin, Khuram Dauod, Azami Rahim, Fazal Monib Rahim, Babulal Ganesh M

机构信息

Brown School, Washington University, St. Louis, MO, USA.

National Conservatory of Arts and Crafts, Paris, France.

出版信息

EClinicalMedicine. 2023 Mar 16;58:101906. doi: 10.1016/j.eclinm.2023.101906. eCollection 2023 Apr.

Abstract

BACKGROUND

Multidimensional poverty is associated with dementia, but no evidence is available for countries in conflict.

METHODS

A cross-sectional study was conducted in two provinces of Afghanistan between February 15th 2022 and April 20th 2022 among adults age 50 and older. Multidimensional poverty included six dimensions of well-being and 16 indicators of deprivation. The Rowland Universal Dementia Assessment Scale measured dementia. Poverty between adults with and without dementia was examined, adjusting for sex. Associations between dementia and poverty were investigated using multivariate regression model.

FINDINGS

Of the 478 adults included, 89 (52.7%) had mild, and 25 (14.8%) had moderate to severe dementia. More women than men had mild (52.7% vs 33.3%) and moderate-to-severe dementia (14.8% vs 5.8%). Approximately 33.9% adults with mild and 51.2% adults with moderate-to-severe dementia were found to be deprived in four or more dimensions compared to 21.8% without dementia. The difference in four dimensions of multidimensional poverty between adults with mild and moderate-to-severe dementia and adults without dementia was respectively 59.5% and 152.88%. Education, employment, health, and living conditions were the main contributors to the adjusted poverty head count ratio. Multidimensional poverty in four or five dimensions was strongly associated with dementia among older adults particularly over 70 years old (odds ratio [OR], 17.38; 95% CI, 2.22-135.63), with greater odds for older women overall (OR, 2.69; 95% CI, 1.76-4.11).

INTERPRETATION

Our findings suggest that early improvement in social determinants of health through targeted structural policies may lower dementia risk later in life. Specifically, better access to free, quality education, healthcare, and basic living standard together with employment opportunities could reduce risk of dementia.

FUNDING

The present study was funded by a grant from the Alzheimer Association (AARG-NTF-21-851241).

摘要

背景

多维贫困与痴呆症相关,但尚无冲突国家的相关证据。

方法

2022年2月15日至2022年4月20日期间,在阿富汗的两个省份对50岁及以上成年人进行了一项横断面研究。多维贫困包括六个幸福维度和16个剥夺指标。采用罗兰通用痴呆评估量表测量痴呆症。对患有和未患痴呆症的成年人的贫困状况进行了检查,并对性别进行了调整。使用多元回归模型研究痴呆症与贫困之间的关联。

结果

在纳入的478名成年人中,89人(52.7%)患有轻度痴呆,25人(14.8%)患有中度至重度痴呆。患有轻度痴呆(52.7%对33.3%)和中度至重度痴呆的女性多于男性(14.8%对5.8%)。与未患痴呆症的成年人相比,约33.9%的轻度痴呆成年人和51.2%的中度至重度痴呆成年人在四个或更多维度上被剥夺。轻度和中度至重度痴呆成年人与未患痴呆症成年人在多维贫困四个维度上的差异分别为59.5%和152.88%。教育、就业、健康和生活条件是调整后的贫困发生率的主要影响因素。四个或五个维度的多维贫困与老年人尤其是70岁以上老年人的痴呆症密切相关(优势比[OR],17.38;95%置信区间,2.22 - 135.63),总体上老年女性的患病几率更高(OR,2.69;95%置信区间,1.76 - 4.11)。

解读

我们的研究结果表明,通过有针对性的结构性政策尽早改善健康的社会决定因素,可能会降低晚年患痴呆症的风险。具体而言,更好地获得免费、优质的教育、医疗保健以及基本生活水平和就业机会可以降低患痴呆症的风险。

资金

本研究由阿尔茨海默病协会的一项赠款(AARG - NTF - 21 - 851241)资助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f22/10030911/6065d8848786/gr1.jpg

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