Bergera-Virassamynaïk Sandrine, Ardiet Nathalie, Sayag Michèle
NAOS Group, Research and Development Department, Aix-en-Provence, 13290, France.
Clin Cosmet Investig Dermatol. 2023 Mar 18;16:677-686. doi: 10.2147/CCID.S401576. eCollection 2023.
Atopic dermatitis (AD) is a chronic relapsing, inflammatory disease which causes eczematous lesions. Itching and symptoms visibility can have a significant impact on quality of life. This is the case when eyelids are affected. Therefore, we evaluated a dermo-cosmetic product designed to care AD on eyelids.
An initial analysis of the product included 20 healthy women with no AD signs. A clinical evaluation of the effect of the product on AD sign severity was performed on 33 subjects presenting AD symptoms on eyelids. We also analyzed the product's capacity to prevent relapses in a parallel group clinical evaluation performed on 66 subjects.
First, on the forearm skin of healthy subjects, the product reduces erythema and decreases transepidermal water loss when used for 28 days. Second, when clinically evaluated on subjects with eyelid symptoms undergoing a corticoid treatment, the product leads to reduced AD signs scored by a dermatologist, better self-evaluation of symptoms by subjects, and improved quality of life. Besides, upon assessment in a randomized controlled clinical evaluation with subjects prone to AD relapses but without symptoms, the product also drastically reduces relapse frequency. If erythema reduction is the only sign identified by a dermatologist, the product greatly and rapidly improves the quality of life of subjects.
These effects can be explained by the known actions of the product's ingredients. Rich in hydrating compounds, fatty acids and anti-inflammatory compounds, it aims at maintaining and restoring the epidermis structure and function to preserve it from irritants. It effectively shows that a daily care and hygiene routine with a dermo-cosmetic product designed according to an ecobiological approach leads to objective improvement of AD and subjective perception of quality of life.
特应性皮炎（AD）是一种慢性复发性炎症性疾病，可导致湿疹样病变。瘙痒和症状可见性会对生活质量产生重大影响。眼睑受累时就是这种情况。因此，我们评估了一种旨在护理眼睑特应性皮炎的皮肤美容产品。
对该产品的初步分析纳入了20名无特应性皮炎体征的健康女性。对33名眼睑出现特应性皮炎症状的受试者进行了该产品对特应性皮炎体征严重程度影响的临床评估。我们还在对66名受试者进行的平行组临床评估中分析了该产品预防复发的能力。
首先，在健康受试者的前臂皮肤上，该产品使用28天时可减轻红斑并减少经表皮水分流失。其次，在对接受皮质类固醇治疗的眼睑症状受试者进行临床评估时，该产品可使皮肤科医生评定的特应性皮炎体征减轻，受试者对症状的自我评估更好，生活质量得到改善。此外，在对有特应性皮炎复发倾向但无症状的受试者进行的随机对照临床评估中，该产品还能大幅降低复发频率。如果皮肤科医生确定的唯一体征是红斑减轻，该产品可极大且迅速地改善受试者的生活质量。
这些效果可以用该产品成分的已知作用来解释。它富含保湿化合物、脂肪酸和抗炎化合物，旨在维持和恢复表皮结构与功能，使其免受刺激物影响。这有效地表明，采用生态生物学方法设计的皮肤美容产品进行日常护理和卫生保健，可客观改善特应性皮炎并主观提升生活质量感受。
