CHU Nantes-Hôtel-Dieu, UF dermato-cancérologie, Inserm U1232, CIC biothérapie Inserm 05031, place Alexis-Ricordeau, 44093 Nantes cedex 01, France.
Eur J Dermatol. 2019 Apr 1;29(S1):15-18. doi: 10.1684/ejd.2019.3535.
The skin is the human body's largest organ colonised by a large community of microorganisms. The ecological community of microorganisms that are present on our body and of the body itself defines the human skin microbiome. Ecobiology is a new scientific approach that is based on the principle that the skin is an ever-evolving ecosystem which interacts with its environment and whose natural resources and mechanisms must be preserved. It explores interconnections and communication between cells as well as between cells and their internal (within the body) and external environments. The close relationship between the host and its inhabitants, the microbiome, is an example for targeted investigations of ecobiology. Exogenous and endogenous factors may lead to dysbiosis. New treatment options that may help the disturbed microbiome to recover and allow the healthy microbiome to maintain its homeostasis may certainly play a future role in dermatology.
皮肤是人体最大的器官，其上定植着大量微生物。存在于人体上的微生物生态群落及其本身定义了人类皮肤微生物组。生态学生物学是一种新的科学方法，其基于以下原理：皮肤是一个不断演变的生态系统，与环境相互作用，其自然资源和机制必须得到保护。它探索了细胞之间以及细胞与其内部（体内）和外部环境之间的相互联系和交流。宿主与其居民（微生物组）之间的密切关系就是生态学生物学的一个目标研究示例。外源性和内源性因素可能导致微生态失调。有助于受干扰的微生物组恢复并使健康的微生物组维持其体内平衡的新治疗选择在未来肯定会在皮肤科发挥作用。
