Liu Yan-Bin, Zuo Li-Juan, Liu Ya-Chao, Li Yan-Ping, Xin Yun-Chao, Zhang Hong-Yan, Hou Li-Yuan
Department of ENT & HN Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei, 075000, People's Republic of China.
Department of Endocrine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei, 075000, People's Republic of China.
Patient Prefer Adherence. 2023 Mar 18;17:731-738. doi: 10.2147/PPA.S400832. eCollection 2023.
This study aimed to design a standard method of psychological intervention and evaluate the effect of such psychological intervention against the psychological distress of differentiated thyroid cancer (DTC) patients in the treatment with radioactive iodine.
The enrolled patients were randomly divided into the intervention group and the control group. Both the patients in the 2 groups received the routine nursing care, while the patients in the intervention group also received the additional standard psychological interventions. The questionnaires including patient health questionnaire-9 (PHQ-9), generalized anxiety disorder 7-item (GAD-7), cancer fatigue scale (CFS) and positive and negative affect schedule (PANAS) were used to assess psychological status. These questionnaires were performed at week 0 (T0), week 8 (T1, immediately after the last time of intervention) and week 24 (T2, 16 weeks after the intervention).
PHQ-9, GAD-7, CFS and Negative Affect (NA) scores measured at T1 and T2 in the intervention group were significantly lower than those in the control group ( < 0.001). And intervention group also had higher positive affect (PA) scores at T1 and T2 ( < 0.001). Furthermore, the changes of PHQ-9, GAD-7, CFS, PA and NA scores from T0 to T1 and T0 to T2 were more evident in the intervention group than in the control group.
Psychological intervention could significantly improve psychological distress of DTC patients in the treatment with radioactive iodine.
本研究旨在设计一种标准的心理干预方法，并评估这种心理干预对分化型甲状腺癌（DTC）患者放射性碘治疗期间心理困扰的影响。
将入选患者随机分为干预组和对照组。两组患者均接受常规护理，而干预组患者还接受额外的标准心理干预。采用包括患者健康问卷-9（PHQ-9）、广泛性焦虑障碍7项量表（GAD-7）、癌症疲劳量表（CFS）和正负性情绪量表（PANAS）在内的问卷来评估心理状态。这些问卷在第0周（T0）、第8周（T1，最后一次干预后立即进行）和第24周（T2，干预后16周）进行。
干预组在T1和T2时测得的PHQ-9、GAD-7、CFS和负性情绪（NA）得分显著低于对照组（<0.001）。干预组在T1和T2时的正性情绪（PA）得分也更高（<0.001）。此外，干预组从T0到T1以及从T0到T2的PHQ-9、GAD-7、CFS、PA和NA得分变化比对照组更明显。
心理干预可显著改善DTC患者放射性碘治疗期间的心理困扰。
