Javaloyes Nuria, Crespo Aurora, Redal M Carmen, Brugarolas Antonio, Botella Lara, Escudero-Ortiz Vanesa, Sureda Manuel
Plataforma de Oncología, Hospital Quirónsalud Torrevieja, Torrevieja, Spain.
Servicio de Medicina Nuclear, Hospital Universitari Sant Joan, Alicante, Spain.
Front Psychol. 2022 Feb 25;13:767093. doi: 10.3389/fpsyg.2022.767093. eCollection 2022.
Diagnosis and treatment of differentiated thyroid carcinomas (DTC) cause anxiety and depression. Additionally, these patients suffer hormonal alterations that are associated with psychological symptoms (e.g., changes in mood, emotional instability, and memory loss). This study aims to evaluate the effectiveness of a psycho-oncological intervention based on counseling to reduce anxiety and depression related to the treatment in patients with DTC.
A non-randomized controlled study, with two groups [experimental group (EG), = 37, and control group (CG), = 38] and baseline and posttreatment measures, was designed. Patients in the EG received a psycho-oncological intervention based on counseling in addition to the standard treatment. The independent variable was the assigned group and the dependent one was the evolution of anxiety and depression, which were analyzed separately, and both were evaluated using the Hospital Anxiety and Depression Scale. Other relevant covariables related to the quality of life (QoL) were also analyzed using Short Form-36 Health Survey and Psychological General Wellbeing Index scales.
The difference of the posttreatment-baseline variation showed a statistically significant reduction in anxiety and depression in the EG in relation to the CG ( < 0.001). The mean of the Psychological General Wellbeing Index scales score increased significantly in the EG ( < 0.001) and decreased significantly in the CG ( < 0.001). All the baseline and the posttreatment scores of the variables evaluated showed a statistically significant improvement in the EG vs. the CG.
This study demonstrates significant benefits of psycho-oncological intervention based on counseling in anxiety, depression, QoL, and wellbeing of the patient with differentiated thyroid carcinomas.
分化型甲状腺癌（DTC）的诊断和治疗会引发焦虑和抑郁。此外，这些患者会出现与心理症状相关的激素变化（如情绪改变、情绪不稳定和记忆力减退）。本研究旨在评估基于咨询的心理肿瘤干预措施对减轻DTC患者治疗相关焦虑和抑郁的有效性。
设计了一项非随机对照研究，分为两组[实验组（EG），n = 37，对照组（CG），n = 38]，并进行基线和治疗后测量。EG组患者在接受标准治疗的基础上，还接受了基于咨询的心理肿瘤干预。自变量是分组，因变量是焦虑和抑郁的变化，分别进行分析，均使用医院焦虑抑郁量表进行评估。还使用简短健康调查问卷和心理综合幸福感指数量表分析了与生活质量（QoL）相关的其他相关协变量。
治疗后与基线变化的差异显示，EG组的焦虑和抑郁相对于CG组有统计学意义的降低（P < 0.001）。EG组心理综合幸福感指数量表得分均值显著升高（P < 0.001），CG组显著降低（P < 0.001）。所评估变量的所有基线和治疗后得分在EG组与CG组之间均显示出统计学意义的改善。
本研究表明，基于咨询的心理肿瘤干预对分化型甲状腺癌患者的焦虑、抑郁、生活质量和幸福感有显著益处。
